| 26 Sep 21 | r01        | Frankfurt SkylinersFrankfurt Sky | 76 - 89 | BraunschweigBraunschweig |
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| 28 Sep 21 | r02        | ALBA BerlinALBA Berlin | 101 - 63 | Frankfurt SkylinersFrankfurt Sky |
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| 10 Oct 21 | r03        | Frankfurt SkylinersFrankfurt Sky | 64 - 74 | Hamburg TowersHamburg Tower |
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| 15 Oct 21 | r04        | BonnBonn | 86 - 76 | Frankfurt SkylinersFrankfurt Sky |
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| 24 Oct 21 | r05        | Frankfurt SkylinersFrankfurt Sky | 50 - 78 | Bayern München BasketballBayern Münche |
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| 30 Oct 21 | r06        | UlmUlm | 80 - 88 | Frankfurt SkylinersFrankfurt Sky |
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| 07 Nov 21 | r07        | Frankfurt SkylinersFrankfurt Sky | 72 - 77 | Brose BambergBrose Bamberg |
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| 21 Nov 21 | r08        | s.Oliver Würzburgs.Oliver Würz | 78 - 83 | Frankfurt SkylinersFrankfurt Sky |
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| 05 Dec 21 | r09        | Frankfurt SkylinersFrankfurt Sky | 80 - 73 | Crailsheim MerlinsCrailsheim Me |
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| 11 Dec 21 | r10        | BayreuthBayreuth | 85 - 72 | Frankfurt SkylinersFrankfurt Sky |
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| 15 Dec 21 | r12        | LudwigsburgLudwigsburg | 95 - 67 | Frankfurt SkylinersFrankfurt Sky |
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| 19 Dec 21 | r11        | Frankfurt SkylinersFrankfurt Sky | 68 - 89 | Mitteldeutscher BCMitteldeutsch |
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| 27 Dec 21 | r13        | Frankfurt SkylinersFrankfurt Sky | 78 - 82 | Niners ChemnitzNiners Chemni |
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| 30 Dec 21 | r14        | Frankfurt SkylinersFrankfurt Sky | 87 - 82 | USC HeidelbergUSC Heidelber |
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| 02 Jan 22 | r15        | Gießen 46ersGießen 46ers | 79 - 90 | Frankfurt SkylinersFrankfurt Sky |
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| 28 Jan 22 | r19        | Niners ChemnitzNiners Chemni | 87 - 86 | Frankfurt SkylinersFrankfurt Sky |
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| 06 Feb 22 | r20        | Frankfurt SkylinersFrankfurt Sky | 71 - 80 | LudwigsburgLudwigsburg |
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| 09 Feb 22 | r16        | Frankfurt SkylinersFrankfurt Sky | 103 - 110 | EWE Baskets OldenburgEWE Baskets O |
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| 13 Feb 22 | r21        | Bayern München BasketballBayern Münche | 72 - 53 | Frankfurt SkylinersFrankfurt Sky |
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| 15 Feb 22 | r22        | Frankfurt SkylinersFrankfurt Sky | 56 - 72 | ALBA BerlinALBA Berlin |
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| 09 Mar 22 | r24        | Frankfurt SkylinersFrankfurt Sky | 65 - 73 | BG GöttingenBG Göttingen |
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| 13 Mar 22 | r25        | Mitteldeutscher BCMitteldeutsch | 81 - 75 | Frankfurt SkylinersFrankfurt Sky |
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| 16 Mar 22 | r18        | Frankfurt SkylinersFrankfurt Sky | 61 - 69 | s.Oliver Würzburgs.Oliver Würz |
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| 20 Mar 22 | r26        | BraunschweigBraunschweig | 67 - 72 | Frankfurt SkylinersFrankfurt Sky |
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| 25 Mar 22 | r27        | Frankfurt SkylinersFrankfurt Sky | 58 - 61 | UlmUlm |
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| 29 Mar 22 | r23        | USC HeidelbergUSC Heidelber | 71 - 65 | Frankfurt SkylinersFrankfurt Sky |
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| 03 Apr 22 | r28        | Brose BambergBrose Bamberg | 75 - 72 | Frankfurt SkylinersFrankfurt Sky |
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| 06 Apr 22 | r17        | BG GöttingenBG Göttingen | 76 - 72 | Frankfurt SkylinersFrankfurt Sky |
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| 10 Apr 22 | r29        | Frankfurt SkylinersFrankfurt Sky | 96 - 112 | BonnBonn |
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| 13 Apr 22 | r30        | Hamburg TowersHamburg Tower | 68 - 58 | Frankfurt SkylinersFrankfurt Sky |
| |
| 18 Apr 22 | r31        | EWE Baskets OldenburgEWE Baskets O | 69 - 88 | Frankfurt SkylinersFrankfurt Sky |
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| 24 Apr 22 | r32        | Frankfurt SkylinersFrankfurt Sky | 75 - 76 | Gießen 46ersGießen 46ers |
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| 29 Apr 22 | r33        | Crailsheim MerlinsCrailsheim Me | 70 - 81 | Frankfurt SkylinersFrankfurt Sky |
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| 01 May 22 | r34        | Frankfurt SkylinersFrankfurt Sky | 82 - 70 | BayreuthBayreuth |