| 25 Sep 21 | r01        | Napoli BasketNapoli Basket | 63 - 73 | Olimpia MilanoOlimpia Milan |
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| 03 Oct 21 | r02        | Pallacanestro ReggianaPallacanestro | 102 - 90 | Napoli BasketNapoli Basket |
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| 10 Oct 21 | r03        | Napoli BasketNapoli Basket | 82 - 70 | Universo Treviso BasketUniverso Trev |
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| 17 Oct 21 | r04        | Basket Brescia LeonessaBasket Bresci | 98 - 88 | Napoli BasketNapoli Basket |
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| 24 Oct 21 | r05        | Napoli BasketNapoli Basket | 92 - 89 | Virtus Pallacanestro BoloVirtus Pallac |
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| 30 Oct 21 | r06        | Pallacanestro TriestePallacanestro | 77 - 75 | Napoli BasketNapoli Basket |
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| 07 Nov 21 | r07        | Napoli BasketNapoli Basket | 82 - 79 | Derthona BasketDerthona Bask |
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| 13 Nov 21 | r08        | Victoria LibertasVictoria Libe | 83 - 100 | Napoli BasketNapoli Basket |
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| 21 Nov 21 | r09        | Dinamo Basket SassariDinamo Basket | 74 - 75 | Napoli BasketNapoli Basket |
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| 05 Dec 21 | r10        | Napoli BasketNapoli Basket | 91 - 88 | Guerino Vanoli BasketGuerino Vanol |
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| 12 Dec 21 | r11        | Pallacanestro VaresePallacanestro | 89 - 98 | Napoli BasketNapoli Basket |
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| 19 Dec 21 | r12        | Napoli BasketNapoli Basket | 72 - 81 | Aquila Basket TrentoAquila Basket |
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| 05 Jan 22 | r13        | Reyer Venezia MestreReyer Venezia | 79 - 75 | Napoli BasketNapoli Basket |
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| 16 Jan 22 | r14        | Napoli BasketNapoli Basket | 86 - 89 | Fortitudo Pallacanestro BFortitudo Pal |
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| 19 Jan 22 | r15        | New Basket BrindisiNew Basket Br | 89 - 75 | Napoli BasketNapoli Basket |
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| 23 Jan 22 | r17        | Aquila Basket TrentoAquila Basket | 85 - 72 | Napoli BasketNapoli Basket |
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| 31 Jan 22 | r18        | Napoli BasketNapoli Basket | 89 - 82 | Pallacanestro TriestePallacanestro |
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| 19 Feb 22 | r19        | Napoli BasketNapoli Basket | 76 - 81 | Reyer Venezia MestreReyer Venezia |
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| 06 Mar 22 | r21        | Virtus Pallacanestro BoloVirtus Pallac | 86 - 75 | Napoli BasketNapoli Basket |
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| 09 Mar 22 | r20        | Guerino Vanoli BasketGuerino Vanol | 96 - 93 | Napoli BasketNapoli Basket |
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| 14 Mar 22 | r22        | Napoli BasketNapoli Basket | 74 - 82 | Pallacanestro VaresePallacanestro |
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| 19 Mar 22 | r23        | Derthona BasketDerthona Bask | 83 - 77 | Napoli BasketNapoli Basket |
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| 27 Mar 22 | r24        | Napoli BasketNapoli Basket | 79 - 69 | New Basket BrindisiNew Basket Br |
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| 03 Apr 22 | r25        | Universo Treviso BasketUniverso Trev | 67 - 77 | Napoli BasketNapoli Basket |
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| 09 Apr 22 | r26        | Napoli BasketNapoli Basket | 68 - 70 | Basket Brescia LeonessaBasket Bresci |
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| 13 Apr 22 | r16        | Napoli BasketNapoli Basket | 82 - 85 | Pallacanestro ReggianaPallacanestro |
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| 16 Apr 22 | r27        | Olimpia MilanoOlimpia Milan | 90 - 67 | Napoli BasketNapoli Basket |
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| 24 Apr 22 | r28        | Napoli BasketNapoli Basket | 72 - 78 | Dinamo Basket SassariDinamo Basket |
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| 01 May 22 | r29        | Fortitudo Pallacanestro BFortitudo Pal | 56 - 64 | Napoli BasketNapoli Basket |
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| 08 May 22 | r30        | Napoli BasketNapoli Basket | 84 - 85 | Victoria LibertasVictoria Libe |