| 05 Feb 22 | r01   | Montevideo City TorqueMontevideo Ci | 1 - 1 | Cerro Largo FCCerro Largo F |
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| 14 Feb 22 | r02  | WanderersWanderers | 1 - 0 | Cerro Largo FCCerro Largo F |
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| 18 Feb 22 | r03 | Cerro Largo FCCerro Largo F | 0 - 5 | Plaza ColoniaPlaza Colonia |
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| 25 Feb 22 | r04 | Boston RiverBoston River | 3 - 0 | Cerro Largo FCCerro Largo F |
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| 05 Mar 22 | r05 | CA River PlateCA River Plat | 1 - 1 | Cerro Largo FCCerro Largo F |
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| 22 Mar 22 | r06 | Cerro Largo FCCerro Largo F | 1 - 0 | CerritoCerrito |
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| 03 Apr 22 | r07 | FenixFenix | 2 - 0 | Cerro Largo FCCerro Largo F |
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| 08 Apr 22 | r08 | Cerro Largo FCCerro Largo F | 0 - 0 | Defensor SportingDefensor Spor |
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| 16 Apr 22 | r09 | Albion FCAlbion FC | 2 - 1 | Cerro Largo FCCerro Largo F |
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| 23 Apr 22 | r10 | Cerro Largo FCCerro Largo F | 0 - 2 | Nacional MontevideoNacional Mont |
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| 08 May 22 | r11 | DanubioDanubio | 2 - 0 | Cerro Largo FCCerro Largo F |
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| 15 May 22 | r12 | Cerro Largo FCCerro Largo F | 1 - 0 | Deportivo MaldonadoDeportivo Mal |
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| 21 May 22 | r13 | RentistasRentistas | 2 - 0 | Cerro Largo FCCerro Largo F |
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| 28 May 22 | r14 | Cerro Largo FCCerro Largo F | 1 - 2 | Liverpool MontevideoLiverpool Mon |
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| 04 Jun 22 | r15 | PeñarolPeñarol | 0 - 1 | Cerro Largo FCCerro Largo F |
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| 12 Jun 22 | r01 | DanubioDanubio | 1 - 1 | Cerro Largo FCCerro Largo F |
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| 20 Jun 22 | r02 | Cerro Largo FCCerro Largo F | 1 - 0 | Plaza ColoniaPlaza Colonia |
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| 25 Jun 22 | r03 | Defensor SportingDefensor Spor | 1 - 0 | Cerro Largo FCCerro Largo F |
| |
| 11 Jul 22 | r04 | CerritoCerrito | 0 - 2 | Cerro Largo FCCerro Largo F |
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| 17 Jul 22 | r05 | Cerro Largo FCCerro Largo F | 0 - 0 | Nacional MontevideoNacional Mont |
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| 20 Jul 22 | r06 | Boston RiverBoston River | 2 - 0 | Cerro Largo FCCerro Largo F |
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| 25 Jul 22 | r07 | Cerro Largo FCCerro Largo F | 0 - 0 | CA River PlateCA River Plat |
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| 31 Jul 22 | r01 | Cerro Largo FCCerro Largo F | 1 - 2 | Montevideo City TorqueMontevideo Ci |
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| 06 Aug 22 | r02 | Cerro Largo FCCerro Largo F | 1 - 1 | WanderersWanderers |
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| 12 Aug 22 | r03 | Plaza ColoniaPlaza Colonia | 2 - 0 | Cerro Largo FCCerro Largo F |
| |
| 20 Aug 22 | r06 | CerritoCerrito | 0 - 0 | Cerro Largo FCCerro Largo F |
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| 29 Aug 22 | r05 | Cerro Largo FCCerro Largo F | 0 - 5 | CA River PlateCA River Plat |
| 29 Aug 22 | r05 | CA River PlateCA River Plat | 0 - 5 | Cerro Largo FCCerro Largo F |
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| 04 Sep 22 | r04 | Cerro Largo FCCerro Largo F | 1 - 1 | Boston RiverBoston River |
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| 11 Sep 22 | r07 | Cerro Largo FCCerro Largo F | 1 - 0 | FenixFenix |
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| 16 Sep 22 | r08 | Defensor SportingDefensor Spor | 0 - 1 | Cerro Largo FCCerro Largo F |
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| 18 Sep 22 | r09 | Cerro Largo FCCerro Largo F | 1 - 2 | Albion FCAlbion FC |
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| 25 Sep 22 | r10 | Nacional MontevideoNacional Mont | 1 - 1 | Cerro Largo FCCerro Largo F |
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| 30 Sep 22 | r11 | Cerro Largo FCCerro Largo F | 1 - 0 | DanubioDanubio |
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| 07 Oct 22 | r12 | Deportivo MaldonadoDeportivo Mal | 0 - 1 | Cerro Largo FCCerro Largo F |
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| 11 Oct 22 | r13 | Cerro Largo FCCerro Largo F | 2 - 1 | RentistasRentistas |
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| 16 Oct 22 | r14 | Liverpool MontevideoLiverpool Mon | 1 - 0 | Cerro Largo FCCerro Largo F |
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| 22 Oct 22 | r15 | Cerro Largo FCCerro Largo F | 0 - 2 | PeñarolPeñarol |
Team 2022 Schedules
Albion
Boston River
Central Español
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Cerro Largo
Danubio
Defensor Sporting
Deportivo Maldonado
Juventud Las Piedras
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Montevideo Wanderers
Nacional Montevideo
Peñarol
Progreso
Racing Montevideo
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