| 06 Feb 22 | r01        | Boston RiverBoston River | 0 - 0 | Plaza ColoniaPlaza Colonia |
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| 13 Feb 22 | r02        | Boston RiverBoston River | 0 - 1 | CerritoCerrito |
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| 19 Feb 22 | r03        | CA River PlateCA River Plat | 1 - 2 | Boston RiverBoston River |
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| 25 Feb 22 | r04        | Boston RiverBoston River | 3 - 0 | Cerro Largo FCCerro Largo F |
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| 12 Mar 22 | r05        | FenixFenix | 0 - 2 | Boston RiverBoston River |
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| 21 Mar 22 | r06        | Boston RiverBoston River | 1 - 1 | Defensor SportingDefensor Spor |
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| 02 Apr 22 | r07        | Albion FCAlbion FC | 1 - 2 | Boston RiverBoston River |
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| 10 Apr 22 | r08        | Boston RiverBoston River | 0 - 6 | Nacional MontevideoNacional Mont |
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| 15 Apr 22 | r09        | DanubioDanubio | 0 - 0 | Boston RiverBoston River |
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| 24 Apr 22 | r10        | Boston RiverBoston River | 2 - 0 | Deportivo MaldonadoDeportivo Mal |
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| 08 May 22 | r11        | RentistasRentistas | 0 - 1 | Boston RiverBoston River |
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| 16 May 22 | r12        | Boston RiverBoston River | 2 - 3 | Liverpool MontevideoLiverpool Mon |
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| 21 May 22 | r13        | PeñarolPeñarol | 1 - 0 | Boston RiverBoston River |
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| 28 May 22 | r14        | Boston RiverBoston River | 3 - 1 | Montevideo City TorqueMontevideo Ci |
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| 06 Jun 22 | r15        | WanderersWanderers | 1 - 2 | Boston RiverBoston River |
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| 14 Jun 22 | r01        | Plaza ColoniaPlaza Colonia | 0 - 0 | Boston RiverBoston River |
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| 20 Jun 22 | r02        | Boston RiverBoston River | 2 - 0 | DanubioDanubio |
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| 26 Jun 22 | r03        | CA River PlateCA River Plat | 0 - 1 | Boston RiverBoston River |
| |
| 10 Jul 22 | r04        | Boston RiverBoston River | 2 - 3 | Defensor SportingDefensor Spor |
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| 16 Jul 22 | r05        | Boston RiverBoston River | 1 - 0 | CerritoCerrito |
| |
| 20 Jul 22 | r06        | Boston RiverBoston River | 2 - 0 | Cerro Largo FCCerro Largo F |
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| 24 Jul 22 | r07        | Nacional MontevideoNacional Mont | 2 - 0 | Boston RiverBoston River |
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| 30 Jul 22 | r01        | Plaza ColoniaPlaza Colonia | 1 - 1 | Boston RiverBoston River |
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| 06 Aug 22 | r02        | CerritoCerrito | 0 - 3 | Boston RiverBoston River |
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| 12 Aug 22 | r03        | Boston RiverBoston River | 1 - 2 | CA River PlateCA River Plat |
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| 21 Aug 22 | r06        | Defensor SportingDefensor Spor | 0 - 1 | Boston RiverBoston River |
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| 26 Aug 22 | r05        | Boston RiverBoston River | 1 - 1 | FenixFenix |
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| 04 Sep 22 | r04        | Cerro Largo FCCerro Largo F | 1 - 1 | Boston RiverBoston River |
| |
| 10 Sep 22 | r07        | Boston RiverBoston River | 1 - 0 | Albion FCAlbion FC |
| |
| 15 Sep 22 | r08        | Nacional MontevideoNacional Mont | 1 - 0 | Boston RiverBoston River |
| |
| 19 Sep 22 | r09        | Boston RiverBoston River | 0 - 1 | DanubioDanubio |
| |
| 23 Sep 22 | r10        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | Boston RiverBoston River |
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| 02 Oct 22 | r11        | Boston RiverBoston River | 3 - 0 | RentistasRentistas |
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| 09 Oct 22 | r12        | Liverpool MontevideoLiverpool Mon | 3 - 2 | Boston RiverBoston River |
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| 12 Oct 22 | r13        | Boston RiverBoston River | 2 - 1 | PeñarolPeñarol |
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| 17 Oct 22 | r14        | Montevideo City TorqueMontevideo Ci | 0 - 2 | Boston RiverBoston River |
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| 24 Oct 22 | r15        | Boston RiverBoston River | 2 - 2 | WanderersWanderers |