| 08 Feb 22 | r01        | CerritoCerrito | 0 - 1 | DanubioDanubio |
| |
| 15 Feb 22 | r02        | Deportivo MaldonadoDeportivo Mal | 1 - 2 | DanubioDanubio |
| |
| 20 Feb 22 | r03        | DanubioDanubio | 0 - 1 | RentistasRentistas |
| |
| 26 Feb 22 | r04        | Liverpool MontevideoLiverpool Mon | 0 - 1 | DanubioDanubio |
| |
| 05 Mar 22 | r05        | DanubioDanubio | 0 - 1 | PeñarolPeñarol |
| |
| 22 Mar 22 | r06        | Montevideo City TorqueMontevideo Ci | 1 - 1 | DanubioDanubio |
| |
| 02 Apr 22 | r07        | DanubioDanubio | 0 - 0 | WanderersWanderers |
| |
| 09 Apr 22 | r08        | Plaza ColoniaPlaza Colonia | 1 - 1 | DanubioDanubio |
| |
| 15 Apr 22 | r09        | DanubioDanubio | 0 - 0 | Boston RiverBoston River |
| |
| 23 Apr 22 | r10        | CA River PlateCA River Plat | 0 - 0 | DanubioDanubio |
| |
| 08 May 22 | r11        | DanubioDanubio | 2 - 0 | Cerro Largo FCCerro Largo F |
| |
| 15 May 22 | r12        | FenixFenix | 0 - 0 | DanubioDanubio |
| |
| 22 May 22 | r13        | DanubioDanubio | 1 - 2 | Defensor SportingDefensor Spor |
| |
| 27 May 22 | r14        | Albion FCAlbion FC | 1 - 2 | DanubioDanubio |
| |
| 05 Jun 22 | r15        | DanubioDanubio | 2 - 1 | Nacional MontevideoNacional Mont |
| |
| 12 Jun 22 | r01        | DanubioDanubio | 1 - 1 | Cerro Largo FCCerro Largo F |
| |
| 20 Jun 22 | r02        | Boston RiverBoston River | 2 - 0 | DanubioDanubio |
| |
| 25 Jun 22 | r03        | DanubioDanubio | 0 - 1 | Nacional MontevideoNacional Mont |
| |
| 10 Jul 22 | r04        | DanubioDanubio | 1 - 3 | CA River PlateCA River Plat |
| |
| 17 Jul 22 | r05        | Defensor SportingDefensor Spor | 2 - 1 | DanubioDanubio |
| |
| 21 Jul 22 | r06        | DanubioDanubio | 2 - 0 | Plaza ColoniaPlaza Colonia |
| |
| 25 Jul 22 | r07        | CerritoCerrito | 0 - 1 | DanubioDanubio |
| |
| 31 Jul 22 | r01        | DanubioDanubio | 0 - 0 | CerritoCerrito |
| |
| 07 Aug 22 | r02        | DanubioDanubio | 0 - 0 | Deportivo MaldonadoDeportivo Mal |
| |
| 13 Aug 22 | r03        | RentistasRentistas | 0 - 1 | DanubioDanubio |
| |
| 19 Aug 22 | r06        | DanubioDanubio | 3 - 2 | Montevideo City TorqueMontevideo Ci |
| |
| 28 Aug 22 | r05        | PeñarolPeñarol | 1 - 1 | DanubioDanubio |
| |
| 03 Sep 22 | r04        | DanubioDanubio | 1 - 1 | Liverpool MontevideoLiverpool Mon |
| |
| 10 Sep 22 | r07        | WanderersWanderers | 0 - 3 | DanubioDanubio |
| |
| 13 Sep 22 | r08        | DanubioDanubio | 1 - 1 | Plaza ColoniaPlaza Colonia |
| |
| 19 Sep 22 | r09        | Boston RiverBoston River | 0 - 1 | DanubioDanubio |
| |
| 24 Sep 22 | r10        | DanubioDanubio | 3 - 0 | CA River PlateCA River Plat |
| |
| 30 Sep 22 | r11        | Cerro Largo FCCerro Largo F | 1 - 0 | DanubioDanubio |
| |
| 08 Oct 22 | r12        | DanubioDanubio | 1 - 1 | FenixFenix |
| |
| 13 Oct 22 | r13        | Defensor SportingDefensor Spor | 1 - 1 | DanubioDanubio |
| |
| 16 Oct 22 | r14        | DanubioDanubio | 3 - 0 | Albion FCAlbion FC |
| |
| 23 Oct 22 | r15        | Nacional MontevideoNacional Mont | 2 - 0 | DanubioDanubio |