| 15 Apr 22 | r09        | DanubioDanubio | 0 - 0 | Boston RiverBoston River |
| 16 Apr 22 | r09        | Defensor SportingDefensor Spor | 2 - 1 | FenixFenix |
| 16 Apr 22 | r09        | Liverpool MontevideoLiverpool Mon | 2 - 0 | Montevideo City TorqueMontevideo Ci |
| 16 Apr 22 | r09        | Albion FCAlbion FC | 2 - 1 | Cerro Largo FCCerro Largo F |
| 16 Apr 22 | r09        | CerritoCerrito | 0 - 0 | PeñarolPeñarol |
| 17 Apr 22 | r09        | Deportivo MaldonadoDeportivo Mal | 3 - 1 | Plaza ColoniaPlaza Colonia |
| 17 Apr 22 | r09        | Nacional MontevideoNacional Mont | 1 - 1 | CA River PlateCA River Plat |
| 18 Apr 22 | r09        | RentistasRentistas | 1 - 3 | WanderersWanderers |
| 17 Sep 22 | r09        | Plaza ColoniaPlaza Colonia | 0 - 1 | Deportivo MaldonadoDeportivo Mal |
| 17 Sep 22 | r09        | CA River PlateCA River Plat | 1 - 1 | Nacional MontevideoNacional Mont |
| 17 Sep 22 | r09        | WanderersWanderers | 1 - 0 | RentistasRentistas |
| 18 Sep 22 | r09        | Cerro Largo FCCerro Largo F | 1 - 2 | Albion FCAlbion FC |
| 18 Sep 22 | r09        | PeñarolPeñarol | 3 - 1 | CerritoCerrito |
| 19 Sep 22 | r09        | Boston RiverBoston River | 0 - 1 | DanubioDanubio |
| 19 Sep 22 | r09        | Montevideo City TorqueMontevideo Ci | 0 - 2 | Liverpool MontevideoLiverpool Mon |
| 20 Sep 22 | r09        | FenixFenix | 0 - 0 | Defensor SportingDefensor Spor |