| 23 Apr 22 | r10        | Cerro Largo FCCerro Largo F | 0 - 2 | Nacional MontevideoNacional Mont |
| 23 Apr 22 | r10        | WanderersWanderers | 0 - 0 | Liverpool MontevideoLiverpool Mon |
| 23 Apr 22 | r10        | CA River PlateCA River Plat | 0 - 0 | DanubioDanubio |
| 23 Apr 22 | r10        | Montevideo City TorqueMontevideo Ci | 0 - 1 | PeñarolPeñarol |
| 24 Apr 22 | r10        | FenixFenix | 2 - 1 | Albion FCAlbion FC |
| 24 Apr 22 | r10        | Boston RiverBoston River | 2 - 0 | Deportivo MaldonadoDeportivo Mal |
| 25 Apr 22 | r10        | Plaza ColoniaPlaza Colonia | 0 - 3 | RentistasRentistas |
| 26 Apr 22 | r10        | Defensor SportingDefensor Spor | 0 - 0 | CerritoCerrito |
| 23 Sep 22 | r10        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | Boston RiverBoston River |
| 24 Sep 22 | r10        | Liverpool MontevideoLiverpool Mon | 1 - 1 | WanderersWanderers |
| 24 Sep 22 | r10        | DanubioDanubio | 3 - 0 | CA River PlateCA River Plat |
| 24 Sep 22 | r10        | PeñarolPeñarol | 0 - 1 | Montevideo City TorqueMontevideo Ci |
| 25 Sep 22 | r10        | RentistasRentistas | 0 - 1 | Plaza ColoniaPlaza Colonia |
| 25 Sep 22 | r10        | Nacional MontevideoNacional Mont | 1 - 1 | Cerro Largo FCCerro Largo F |
| 26 Sep 22 | r10        | CerritoCerrito | 1 - 2 | Defensor SportingDefensor Spor |
| 26 Sep 22 | r10        | Albion FCAlbion FC | 1 - 1 | FenixFenix |