| 08 Apr 22 | r08        | Cerro Largo FCCerro Largo F | 0 - 0 | Defensor SportingDefensor Spor |
| 09 Apr 22 | r08        | PeñarolPeñarol | 2 - 1 | Liverpool MontevideoLiverpool Mon |
| 09 Apr 22 | r08        | Plaza ColoniaPlaza Colonia | 1 - 1 | DanubioDanubio |
| 10 Apr 22 | r08        | FenixFenix | 2 - 0 | CerritoCerrito |
| 10 Apr 22 | r08        | CA River PlateCA River Plat | 4 - 1 | Albion FCAlbion FC |
| 10 Apr 22 | r08        | Boston RiverBoston River | 0 - 6 | Nacional MontevideoNacional Mont |
| 11 Apr 22 | r08        | WanderersWanderers | 0 - 1 | Deportivo MaldonadoDeportivo Mal |
| 12 Apr 22 | r08        | Montevideo City TorqueMontevideo Ci | 2 - 0 | RentistasRentistas |
| 13 Sep 22 | r08        | DanubioDanubio | 1 - 1 | Plaza ColoniaPlaza Colonia |
| 13 Sep 22 | r08        | Deportivo MaldonadoDeportivo Mal | 1 - 0 | WanderersWanderers |
| 14 Sep 22 | r08        | RentistasRentistas | 3 - 0 | Montevideo City TorqueMontevideo Ci |
| 14 Sep 22 | r08        | Albion FCAlbion FC | 0 - 2 | CA River PlateCA River Plat |
| 15 Sep 22 | r08        | Nacional MontevideoNacional Mont | 1 - 0 | Boston RiverBoston River |
| 15 Sep 22 | r08        | CerritoCerrito | 0 - 2 | FenixFenix |
| 15 Sep 22 | r08        | Liverpool MontevideoLiverpool Mon | 0 - 1 | PeñarolPeñarol |
| 16 Sep 22 | r08        | Defensor SportingDefensor Spor | 0 - 1 | Cerro Largo FCCerro Largo F |