| 05 Feb 22 | r01        | Montevideo City TorqueMontevideo Ci | 1 - 1 | Cerro Largo FCCerro Largo F |
| 05 Feb 22 | r01        | FenixFenix | 1 - 0 | PeñarolPeñarol |
| 05 Feb 22 | r01        | Defensor SportingDefensor Spor | 0 - 3 | Liverpool MontevideoLiverpool Mon |
| 06 Feb 22 | r01        | Albion FCAlbion FC | 3 - 5 | RentistasRentistas |
| 06 Feb 22 | r01        | Boston RiverBoston River | 0 - 0 | Plaza ColoniaPlaza Colonia |
| 06 Feb 22 | r01        | Nacional MontevideoNacional Mont | 2 - 3 | Deportivo MaldonadoDeportivo Mal |
| 07 Feb 22 | r01        | CA River PlateCA River Plat | 1 - 1 | WanderersWanderers |
| 08 Feb 22 | r01        | CerritoCerrito | 0 - 1 | DanubioDanubio |
| |
| 11 Feb 22 | r02        | Montevideo City TorqueMontevideo Ci | 1 - 2 | FenixFenix |
| 12 Feb 22 | r02        | Plaza ColoniaPlaza Colonia | 0 - 1 | CA River PlateCA River Plat |
| 12 Feb 22 | r02        | RentistasRentistas | 0 - 4 | Nacional MontevideoNacional Mont |
| 13 Feb 22 | r02        | Liverpool MontevideoLiverpool Mon | 4 - 0 | Albion FCAlbion FC |
| 13 Feb 22 | r02        | Boston RiverBoston River | 0 - 1 | CerritoCerrito |
| 13 Feb 22 | r02        | PeñarolPeñarol | 0 - 1 | Defensor SportingDefensor Spor |
| 14 Feb 22 | r02        | WanderersWanderers | 1 - 0 | Cerro Largo FCCerro Largo F |
| 15 Feb 22 | r02        | Deportivo MaldonadoDeportivo Mal | 1 - 2 | DanubioDanubio |
| |
| 18 Feb 22 | r03        | Cerro Largo FCCerro Largo F | 0 - 5 | Plaza ColoniaPlaza Colonia |
| 19 Feb 22 | r03        | CA River PlateCA River Plat | 1 - 2 | Boston RiverBoston River |
| 19 Feb 22 | r03        | Defensor SportingDefensor Spor | 1 - 3 | Montevideo City TorqueMontevideo Ci |
| 19 Feb 22 | r03        | Albion FCAlbion FC | 1 - 1 | PeñarolPeñarol |
| 20 Feb 22 | r03        | FenixFenix | 0 - 3 | WanderersWanderers |
| 20 Feb 22 | r03        | DanubioDanubio | 0 - 1 | RentistasRentistas |
| 21 Feb 22 | r03        | CerritoCerrito | 0 - 3 | Deportivo MaldonadoDeportivo Mal |
| 21 Feb 22 | r03        | Nacional MontevideoNacional Mont | 0 - 0 | Liverpool MontevideoLiverpool Mon |
| |
| 25 Feb 22 | r04        | Boston RiverBoston River | 3 - 0 | Cerro Largo FCCerro Largo F |
| 25 Feb 22 | r04        | Plaza ColoniaPlaza Colonia | 1 - 1 | FenixFenix |
| 26 Feb 22 | r04        | RentistasRentistas | 1 - 2 | Deportivo MaldonadoDeportivo Mal |
| 26 Feb 22 | r04        | Liverpool MontevideoLiverpool Mon | 0 - 1 | DanubioDanubio |
| 26 Feb 22 | r04        | WanderersWanderers | 1 - 0 | Defensor SportingDefensor Spor |
| 27 Feb 22 | r04        | PeñarolPeñarol | 1 - 0 | Nacional MontevideoNacional Mont |
| 28 Feb 22 | r04        | CA River PlateCA River Plat | 3 - 1 | CerritoCerrito |
| 28 Feb 22 | r04        | Montevideo City TorqueMontevideo Ci | 1 - 2 | Albion FCAlbion FC |
| |
| 04 Mar 22 | r05        | Deportivo MaldonadoDeportivo Mal | 1 - 0 | Liverpool MontevideoLiverpool Mon |
| 05 Mar 22 | r05        | CA River PlateCA River Plat | 1 - 1 | Cerro Largo FCCerro Largo F |
| 05 Mar 22 | r05        | DanubioDanubio | 0 - 1 | PeñarolPeñarol |
| 11 Mar 22 | r05        | CerritoCerrito | 2 - 1 | RentistasRentistas |
| 12 Mar 22 | r05        | FenixFenix | 0 - 2 | Boston RiverBoston River |
| 12 Mar 22 | r05        | Defensor SportingDefensor Spor | 0 - 0 | Plaza ColoniaPlaza Colonia |
| 13 Mar 22 | r05        | Albion FCAlbion FC | 1 - 1 | WanderersWanderers |
| 13 Mar 22 | r05        | Nacional MontevideoNacional Mont | 1 - 1 | Montevideo City TorqueMontevideo Ci |
| |
| 19 Mar 22 | r06        | PeñarolPeñarol | 1 - 1 | Deportivo MaldonadoDeportivo Mal |
| 19 Mar 22 | r06        | Plaza ColoniaPlaza Colonia | 1 - 1 | Albion FCAlbion FC |
| 20 Mar 22 | r06        | Liverpool MontevideoLiverpool Mon | 1 - 0 | RentistasRentistas |
| 20 Mar 22 | r06        | CA River PlateCA River Plat | 3 - 1 | FenixFenix |
| 20 Mar 22 | r06        | WanderersWanderers | 2 - 2 | Nacional MontevideoNacional Mont |
| 21 Mar 22 | r06        | Boston RiverBoston River | 1 - 1 | Defensor SportingDefensor Spor |
| 22 Mar 22 | r06        | Montevideo City TorqueMontevideo Ci | 1 - 1 | DanubioDanubio |
| 22 Mar 22 | r06        | Cerro Largo FCCerro Largo F | 1 - 0 | CerritoCerrito |
| |
| 02 Apr 22 | r07        | Albion FCAlbion FC | 1 - 2 | Boston RiverBoston River |
| 02 Apr 22 | r07        | DanubioDanubio | 0 - 0 | WanderersWanderers |
| 02 Apr 22 | r07        | Nacional MontevideoNacional Mont | 1 - 0 | Plaza ColoniaPlaza Colonia |
| 03 Apr 22 | r07        | RentistasRentistas | 0 - 0 | PeñarolPeñarol |
| 03 Apr 22 | r07        | Defensor SportingDefensor Spor | 3 - 2 | CA River PlateCA River Plat |
| 03 Apr 22 | r07        | FenixFenix | 2 - 0 | Cerro Largo FCCerro Largo F |
| 03 Apr 22 | r07        | CerritoCerrito | 0 - 1 | Liverpool MontevideoLiverpool Mon |
| 05 Apr 22 | r07        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | Montevideo City TorqueMontevideo Ci |
| |
| 08 Apr 22 | r08        | Cerro Largo FCCerro Largo F | 0 - 0 | Defensor SportingDefensor Spor |
| 09 Apr 22 | r08        | PeñarolPeñarol | 2 - 1 | Liverpool MontevideoLiverpool Mon |
| 09 Apr 22 | r08        | Plaza ColoniaPlaza Colonia | 1 - 1 | DanubioDanubio |
| 10 Apr 22 | r08        | FenixFenix | 2 - 0 | CerritoCerrito |
| 10 Apr 22 | r08        | CA River PlateCA River Plat | 4 - 1 | Albion FCAlbion FC |
| 10 Apr 22 | r08        | Boston RiverBoston River | 0 - 6 | Nacional MontevideoNacional Mont |
| 11 Apr 22 | r08        | WanderersWanderers | 0 - 1 | Deportivo MaldonadoDeportivo Mal |
| 12 Apr 22 | r08        | Montevideo City TorqueMontevideo Ci | 2 - 0 | RentistasRentistas |
| |
| 15 Apr 22 | r09        | DanubioDanubio | 0 - 0 | Boston RiverBoston River |
| 16 Apr 22 | r09        | Defensor SportingDefensor Spor | 2 - 1 | FenixFenix |
| 16 Apr 22 | r09        | Liverpool MontevideoLiverpool Mon | 2 - 0 | Montevideo City TorqueMontevideo Ci |
| 16 Apr 22 | r09        | Albion FCAlbion FC | 2 - 1 | Cerro Largo FCCerro Largo F |
| 16 Apr 22 | r09        | CerritoCerrito | 0 - 0 | PeñarolPeñarol |
| 17 Apr 22 | r09        | Deportivo MaldonadoDeportivo Mal | 3 - 1 | Plaza ColoniaPlaza Colonia |
| 17 Apr 22 | r09        | Nacional MontevideoNacional Mont | 1 - 1 | CA River PlateCA River Plat |
| 18 Apr 22 | r09        | RentistasRentistas | 1 - 3 | WanderersWanderers |
| |
| 23 Apr 22 | r10        | Cerro Largo FCCerro Largo F | 0 - 2 | Nacional MontevideoNacional Mont |
| 23 Apr 22 | r10        | WanderersWanderers | 0 - 0 | Liverpool MontevideoLiverpool Mon |
| 23 Apr 22 | r10        | CA River PlateCA River Plat | 0 - 0 | DanubioDanubio |
| 23 Apr 22 | r10        | Montevideo City TorqueMontevideo Ci | 0 - 1 | PeñarolPeñarol |
| 24 Apr 22 | r10        | FenixFenix | 2 - 1 | Albion FCAlbion FC |
| 24 Apr 22 | r10        | Boston RiverBoston River | 2 - 0 | Deportivo MaldonadoDeportivo Mal |
| 25 Apr 22 | r10        | Plaza ColoniaPlaza Colonia | 0 - 3 | RentistasRentistas |
| 26 Apr 22 | r10        | Defensor SportingDefensor Spor | 0 - 0 | CerritoCerrito |
| |
| 06 May 22 | r11        | CerritoCerrito | 2 - 2 | Montevideo City TorqueMontevideo Ci |
| 07 May 22 | r11        | Albion FCAlbion FC | 0 - 3 | Defensor SportingDefensor Spor |
| 07 May 22 | r11        | Liverpool MontevideoLiverpool Mon | 1 - 0 | Plaza ColoniaPlaza Colonia |
| 07 May 22 | r11        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | CA River PlateCA River Plat |
| 08 May 22 | r11        | RentistasRentistas | 0 - 1 | Boston RiverBoston River |
| 08 May 22 | r11        | DanubioDanubio | 2 - 0 | Cerro Largo FCCerro Largo F |
| 08 May 22 | r11        | PeñarolPeñarol | 1 - 0 | WanderersWanderers |
| 09 May 22 | r11        | Nacional MontevideoNacional Mont | 1 - 0 | FenixFenix |
| |
| 13 May 22 | r12        | CA River PlateCA River Plat | 1 - 0 | RentistasRentistas |
| 14 May 22 | r12        | Plaza ColoniaPlaza Colonia | 0 - 1 | PeñarolPeñarol |
| 14 May 22 | r12        | Defensor SportingDefensor Spor | 0 - 2 | Nacional MontevideoNacional Mont |
| 15 May 22 | r12        | WanderersWanderers | 1 - 1 | Montevideo City TorqueMontevideo Ci |
| 15 May 22 | r12        | Cerro Largo FCCerro Largo F | 1 - 0 | Deportivo MaldonadoDeportivo Mal |
| 15 May 22 | r12        | FenixFenix | 0 - 0 | DanubioDanubio |
| 15 May 22 | r12        | Albion FCAlbion FC | 2 - 2 | CerritoCerrito |
| 16 May 22 | r12        | Boston RiverBoston River | 2 - 3 | Liverpool MontevideoLiverpool Mon |
| |
| 21 May 22 | r13        | Deportivo MaldonadoDeportivo Mal | 0 - 1 | FenixFenix |
| 21 May 22 | r13        | RentistasRentistas | 2 - 0 | Cerro Largo FCCerro Largo F |
| 21 May 22 | r13        | Nacional MontevideoNacional Mont | 2 - 0 | Albion FCAlbion FC |
| 21 May 22 | r13        | PeñarolPeñarol | 1 - 0 | Boston RiverBoston River |
| 22 May 22 | r13        | Liverpool MontevideoLiverpool Mon | 2 - 1 | CA River PlateCA River Plat |
| 22 May 22 | r13        | DanubioDanubio | 1 - 2 | Defensor SportingDefensor Spor |
| 22 May 22 | r13        | CerritoCerrito | 0 - 2 | WanderersWanderers |
| 23 May 22 | r13        | Montevideo City TorqueMontevideo Ci | 1 - 1 | Plaza ColoniaPlaza Colonia |
| |
| 27 May 22 | r14        | Albion FCAlbion FC | 1 - 2 | DanubioDanubio |
| 28 May 22 | r14        | Cerro Largo FCCerro Largo F | 1 - 2 | Liverpool MontevideoLiverpool Mon |
| 28 May 22 | r14        | Boston RiverBoston River | 3 - 1 | Montevideo City TorqueMontevideo Ci |
| 29 May 22 | r14        | Nacional MontevideoNacional Mont | 3 - 0 | CerritoCerrito |
| 29 May 22 | r14        | Plaza ColoniaPlaza Colonia | 1 - 0 | WanderersWanderers |
| 29 May 22 | r14        | CA River PlateCA River Plat | 0 - 0 | PeñarolPeñarol |
| 29 May 22 | r14        | Defensor SportingDefensor Spor | 1 - 1 | Deportivo MaldonadoDeportivo Mal |
| 30 May 22 | r14        | FenixFenix | 2 - 1 | RentistasRentistas |
| |
| 03 Jun 22 | r15        | Montevideo City TorqueMontevideo Ci | 0 - 0 | CA River PlateCA River Plat |
| 04 Jun 22 | r15        | PeñarolPeñarol | 0 - 1 | Cerro Largo FCCerro Largo F |
| 04 Jun 22 | r15        | Deportivo MaldonadoDeportivo Mal | 0 - 0 | Albion FCAlbion FC |
| 04 Jun 22 | r15        | CerritoCerrito | 1 - 1 | Plaza ColoniaPlaza Colonia |
| 05 Jun 22 | r15        | RentistasRentistas | 1 - 0 | Defensor SportingDefensor Spor |
| 05 Jun 22 | r15        | Liverpool MontevideoLiverpool Mon | 1 - 0 | FenixFenix |
| 05 Jun 22 | r15        | DanubioDanubio | 2 - 1 | Nacional MontevideoNacional Mont |
| 06 Jun 22 | r15        | WanderersWanderers | 1 - 2 | Boston RiverBoston River |
| |
| 10 Jun 22 | r01        | RentistasRentistas | 1 - 1 | Deportivo MaldonadoDeportivo Mal |
| 10 Jun 22 | r01        | CA River PlateCA River Plat | 3 - 0 | CerritoCerrito |
| 12 Jun 22 | r01        | WanderersWanderers | 1 - 0 | Liverpool MontevideoLiverpool Mon |
| 12 Jun 22 | r01        | DanubioDanubio | 1 - 1 | Cerro Largo FCCerro Largo F |
| 12 Jun 22 | r01        | PeñarolPeñarol | 1 - 2 | Montevideo City TorqueMontevideo Ci |
| 13 Jun 22 | r01        | FenixFenix | 0 - 1 | Albion FCAlbion FC |
| 13 Jun 22 | r01        | Defensor SportingDefensor Spor | 0 - 1 | Nacional MontevideoNacional Mont |
| 14 Jun 22 | r01        | Plaza ColoniaPlaza Colonia | 0 - 0 | Boston RiverBoston River |
| |
| 18 Jun 22 | r02        | Albion FCAlbion FC | 1 - 1 | WanderersWanderers |
| 18 Jun 22 | r02        | Liverpool MontevideoLiverpool Mon | 2 - 2 | FenixFenix |
| 18 Jun 22 | r02        | Nacional MontevideoNacional Mont | 3 - 0 | CA River PlateCA River Plat |
| 19 Jun 22 | r02        | Montevideo City TorqueMontevideo Ci | 3 - 1 | RentistasRentistas |
| 19 Jun 22 | r02        | Deportivo MaldonadoDeportivo Mal | 1 - 3 | PeñarolPeñarol |
| 20 Jun 22 | r02        | CerritoCerrito | 1 - 2 | Defensor SportingDefensor Spor |
| 20 Jun 22 | r02        | Boston RiverBoston River | 2 - 0 | DanubioDanubio |
| 20 Jun 22 | r02        | Cerro Largo FCCerro Largo F | 1 - 0 | Plaza ColoniaPlaza Colonia |
| |
| 25 Jun 22 | r03        | FenixFenix | 0 - 0 | Deportivo MaldonadoDeportivo Mal |
| 25 Jun 22 | r03        | DanubioDanubio | 0 - 1 | Nacional MontevideoNacional Mont |
| 25 Jun 22 | r03        | Defensor SportingDefensor Spor | 1 - 0 | Cerro Largo FCCerro Largo F |
| 26 Jun 22 | r03        | CA River PlateCA River Plat | 0 - 1 | Boston RiverBoston River |
| 26 Jun 22 | r03        | Plaza ColoniaPlaza Colonia | 3 - 0 | CerritoCerrito |
| 26 Jun 22 | r03        | PeñarolPeñarol | 0 - 1 | Liverpool MontevideoLiverpool Mon |
| 27 Jun 22 | r03        | RentistasRentistas | 0 - 1 | Albion FCAlbion FC |
| 27 Jun 22 | r03        | WanderersWanderers | 1 - 0 | Montevideo City TorqueMontevideo Ci |
| |
| 08 Jul 22 | r04        | Albion FCAlbion FC | 1 - 0 | Montevideo City TorqueMontevideo Ci |
| 09 Jul 22 | r04        | Deportivo MaldonadoDeportivo Mal | 1 - 2 | WanderersWanderers |
| 09 Jul 22 | r04        | Liverpool MontevideoLiverpool Mon | 2 - 0 | RentistasRentistas |
| 10 Jul 22 | r04        | Nacional MontevideoNacional Mont | 3 - 1 | Plaza ColoniaPlaza Colonia |
| 10 Jul 22 | r04        | DanubioDanubio | 1 - 3 | CA River PlateCA River Plat |
| 10 Jul 22 | r04        | Boston RiverBoston River | 2 - 3 | Defensor SportingDefensor Spor |
| 10 Jul 22 | r04        | PeñarolPeñarol | 0 - 0 | FenixFenix |
| 11 Jul 22 | r04        | CerritoCerrito | 0 - 2 | Cerro Largo FCCerro Largo F |
| |
| 14 Jul 22 | r05        | Montevideo City TorqueMontevideo Ci | 2 - 3 | Liverpool MontevideoLiverpool Mon |
| 15 Jul 22 | r05        | Albion FCAlbion FC | 2 - 3 | Deportivo MaldonadoDeportivo Mal |
| 15 Jul 22 | r05        | Plaza ColoniaPlaza Colonia | 0 - 0 | CA River PlateCA River Plat |
| 16 Jul 22 | r05        | RentistasRentistas | 0 - 1 | FenixFenix |
| 16 Jul 22 | r05        | Boston RiverBoston River | 1 - 0 | CerritoCerrito |
| 16 Jul 22 | r05        | WanderersWanderers | 3 - 3 | PeñarolPeñarol |
| 17 Jul 22 | r05        | Cerro Largo FCCerro Largo F | 0 - 0 | Nacional MontevideoNacional Mont |
| 17 Jul 22 | r05        | Defensor SportingDefensor Spor | 2 - 1 | DanubioDanubio |
| |
| 19 Jul 22 | r06        | Liverpool MontevideoLiverpool Mon | 0 - 0 | Albion FCAlbion FC |
| 19 Jul 22 | r06        | Deportivo MaldonadoDeportivo Mal | 1 - 1 | Montevideo City TorqueMontevideo Ci |
| 20 Jul 22 | r06        | FenixFenix | 1 - 0 | WanderersWanderers |
| 20 Jul 22 | r06        | Boston RiverBoston River | 2 - 0 | Cerro Largo FCCerro Largo F |
| 21 Jul 22 | r06        | DanubioDanubio | 2 - 0 | Plaza ColoniaPlaza Colonia |
| 21 Jul 22 | r06        | CA River PlateCA River Plat | 1 - 1 | Defensor SportingDefensor Spor |
| 21 Jul 22 | r06        | Nacional MontevideoNacional Mont | 5 - 0 | CerritoCerrito |
| |
| 23 Jul 22 | r07        | Liverpool MontevideoLiverpool Mon | 3 - 1 | Deportivo MaldonadoDeportivo Mal |
| 23 Jul 22 | r07        | Albion FCAlbion FC | 1 - 3 | PeñarolPeñarol |
| 23 Jul 22 | r07        | WanderersWanderers | 3 - 1 | RentistasRentistas |
| 24 Jul 22 | r07        | Montevideo City TorqueMontevideo Ci | 2 - 0 | FenixFenix |
| 24 Jul 22 | r07        | Defensor SportingDefensor Spor | 1 - 2 | Plaza ColoniaPlaza Colonia |
| 24 Jul 22 | r07        | Nacional MontevideoNacional Mont | 2 - 0 | Boston RiverBoston River |
| 25 Jul 22 | r07        | CerritoCerrito | 0 - 1 | DanubioDanubio |
| 25 Jul 22 | r07        | Cerro Largo FCCerro Largo F | 0 - 0 | CA River PlateCA River Plat |
| |
| 26 Jul 22 | r06        | PeñarolPeñarol | 2 - 0 | RentistasRentistas |
| |
| 30 Jul 22 | r01        | RentistasRentistas | 2 - 4 | Albion FCAlbion FC |
| 30 Jul 22 | r01        | Plaza ColoniaPlaza Colonia | 1 - 1 | Boston RiverBoston River |
| 30 Jul 22 | r01        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | Nacional MontevideoNacional Mont |
| 31 Jul 22 | r01        | DanubioDanubio | 0 - 0 | CerritoCerrito |
| 31 Jul 22 | r01        | Cerro Largo FCCerro Largo F | 1 - 2 | Montevideo City TorqueMontevideo Ci |
| 31 Jul 22 | r01        | WanderersWanderers | 1 - 2 | CA River PlateCA River Plat |
| 01 Aug 22 | r01        | Liverpool MontevideoLiverpool Mon | 1 - 3 | Defensor SportingDefensor Spor |
| 02 Aug 22 | r01        | PeñarolPeñarol | 0 - 1 | FenixFenix |
| |
| 06 Aug 22 | r02        | Nacional MontevideoNacional Mont | 3 - 0 | RentistasRentistas |
| 06 Aug 22 | r02        | CA River PlateCA River Plat | 2 - 0 | Plaza ColoniaPlaza Colonia |
| 06 Aug 22 | r02        | Cerro Largo FCCerro Largo F | 1 - 1 | WanderersWanderers |
| 06 Aug 22 | r02        | CerritoCerrito | 0 - 3 | Boston RiverBoston River |
| 07 Aug 22 | r02        | FenixFenix | 1 - 0 | Montevideo City TorqueMontevideo Ci |
| 07 Aug 22 | r02        | DanubioDanubio | 0 - 0 | Deportivo MaldonadoDeportivo Mal |
| 07 Aug 22 | r02        | Defensor SportingDefensor Spor | 2 - 3 | PeñarolPeñarol |
| 08 Aug 22 | r02        | Albion FCAlbion FC | 1 - 1 | Liverpool MontevideoLiverpool Mon |
| |
| 11 Aug 22 | r03        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | CerritoCerrito |
| 11 Aug 22 | r03        | WanderersWanderers | 2 - 1 | FenixFenix |
| 12 Aug 22 | r03        | Boston RiverBoston River | 1 - 2 | CA River PlateCA River Plat |
| 12 Aug 22 | r03        | Plaza ColoniaPlaza Colonia | 2 - 0 | Cerro Largo FCCerro Largo F |
| 13 Aug 22 | r03        | RentistasRentistas | 0 - 1 | DanubioDanubio |
| 13 Aug 22 | r03        | PeñarolPeñarol | 2 - 0 | Albion FCAlbion FC |
| 14 Aug 22 | r03        | Montevideo City TorqueMontevideo Ci | 0 - 2 | Defensor SportingDefensor Spor |
| 14 Aug 22 | r03        | Liverpool MontevideoLiverpool Mon | 0 - 1 | Nacional MontevideoNacional Mont |
| |
| 19 Aug 22 | r06        | DanubioDanubio | 3 - 2 | Montevideo City TorqueMontevideo Ci |
| 20 Aug 22 | r06        | CerritoCerrito | 0 - 0 | Cerro Largo FCCerro Largo F |
| 20 Aug 22 | r06        | RentistasRentistas | 0 - 2 | Liverpool MontevideoLiverpool Mon |
| 20 Aug 22 | r06        | FenixFenix | 1 - 2 | CA River PlateCA River Plat |
| 20 Aug 22 | r06        | Nacional MontevideoNacional Mont | 2 - 0 | WanderersWanderers |
| 21 Aug 22 | r06        | Defensor SportingDefensor Spor | 0 - 1 | Boston RiverBoston River |
| 22 Aug 22 | r06        | Albion FCAlbion FC | 1 - 0 | Plaza ColoniaPlaza Colonia |
| 22 Aug 22 | r06        | Deportivo MaldonadoDeportivo Mal | 1 - 1 | PeñarolPeñarol |
| |
| 26 Aug 22 | r05        | Boston RiverBoston River | 1 - 1 | FenixFenix |
| 27 Aug 22 | r05        | WanderersWanderers | 0 - 0 | Albion FCAlbion FC |
| 27 Aug 22 | r05        | RentistasRentistas | 3 - 0 | CerritoCerrito |
| 27 Aug 22 | r05        | Montevideo City TorqueMontevideo Ci | 0 - 3 | Nacional MontevideoNacional Mont |
| 28 Aug 22 | r05        | Liverpool MontevideoLiverpool Mon | 1 - 1 | Deportivo MaldonadoDeportivo Mal |
| 28 Aug 22 | r05        | Plaza ColoniaPlaza Colonia | 0 - 1 | Defensor SportingDefensor Spor |
| 28 Aug 22 | r05        | PeñarolPeñarol | 1 - 1 | DanubioDanubio |
| 29 Aug 22 | r05        | Cerro Largo FCCerro Largo F | 0 - 5 | CA River PlateCA River Plat |
| 29 Aug 22 | r05        | CA River PlateCA River Plat | 0 - 5 | Cerro Largo FCCerro Largo F |
| |
| 02 Sep 22 | r04        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | RentistasRentistas |
| 03 Sep 22 | r04        | Albion FCAlbion FC | 1 - 0 | Montevideo City TorqueMontevideo Ci |
| 03 Sep 22 | r04        | DanubioDanubio | 1 - 1 | Liverpool MontevideoLiverpool Mon |
| 03 Sep 22 | r04        | Defensor SportingDefensor Spor | 1 - 0 | WanderersWanderers |
| 04 Sep 22 | r04        | Nacional MontevideoNacional Mont | 3 - 1 | PeñarolPeñarol |
| 04 Sep 22 | r04        | Cerro Largo FCCerro Largo F | 1 - 1 | Boston RiverBoston River |
| 05 Sep 22 | r04        | CerritoCerrito | 1 - 5 | CA River PlateCA River Plat |
| 05 Sep 22 | r04        | FenixFenix | 0 - 1 | Plaza ColoniaPlaza Colonia |
| |
| 09 Sep 22 | r07        | Liverpool MontevideoLiverpool Mon | 3 - 0 | CerritoCerrito |
| 09 Sep 22 | r07        | Montevideo City TorqueMontevideo Ci | 3 - 3 | Deportivo MaldonadoDeportivo Mal |
| 10 Sep 22 | r07        | WanderersWanderers | 0 - 3 | DanubioDanubio |
| 10 Sep 22 | r07        | Boston RiverBoston River | 1 - 0 | Albion FCAlbion FC |
| 10 Sep 22 | r07        | Plaza ColoniaPlaza Colonia | 1 - 3 | Nacional MontevideoNacional Mont |
| 11 Sep 22 | r07        | CA River PlateCA River Plat | 0 - 1 | Defensor SportingDefensor Spor |
| 11 Sep 22 | r07        | Cerro Largo FCCerro Largo F | 1 - 0 | FenixFenix |
| 11 Sep 22 | r07        | PeñarolPeñarol | 2 - 2 | RentistasRentistas |
| |
| 13 Sep 22 | r08        | DanubioDanubio | 1 - 1 | Plaza ColoniaPlaza Colonia |
| 13 Sep 22 | r08        | Deportivo MaldonadoDeportivo Mal | 1 - 0 | WanderersWanderers |
| 14 Sep 22 | r08        | RentistasRentistas | 3 - 0 | Montevideo City TorqueMontevideo Ci |
| 14 Sep 22 | r08        | Albion FCAlbion FC | 0 - 2 | CA River PlateCA River Plat |
| 15 Sep 22 | r08        | Nacional MontevideoNacional Mont | 1 - 0 | Boston RiverBoston River |
| 15 Sep 22 | r08        | CerritoCerrito | 0 - 2 | FenixFenix |
| 15 Sep 22 | r08        | Liverpool MontevideoLiverpool Mon | 0 - 1 | PeñarolPeñarol |
| 16 Sep 22 | r08        | Defensor SportingDefensor Spor | 0 - 1 | Cerro Largo FCCerro Largo F |
| |
| 17 Sep 22 | r09        | Plaza ColoniaPlaza Colonia | 0 - 1 | Deportivo MaldonadoDeportivo Mal |
| 17 Sep 22 | r09        | CA River PlateCA River Plat | 1 - 1 | Nacional MontevideoNacional Mont |
| 17 Sep 22 | r09        | WanderersWanderers | 1 - 0 | RentistasRentistas |
| 18 Sep 22 | r09        | Cerro Largo FCCerro Largo F | 1 - 2 | Albion FCAlbion FC |
| 18 Sep 22 | r09        | PeñarolPeñarol | 3 - 1 | CerritoCerrito |
| 19 Sep 22 | r09        | Boston RiverBoston River | 0 - 1 | DanubioDanubio |
| 19 Sep 22 | r09        | Montevideo City TorqueMontevideo Ci | 0 - 2 | Liverpool MontevideoLiverpool Mon |
| 20 Sep 22 | r09        | FenixFenix | 0 - 0 | Defensor SportingDefensor Spor |
| |
| 23 Sep 22 | r10        | Deportivo MaldonadoDeportivo Mal | 2 - 1 | Boston RiverBoston River |
| 24 Sep 22 | r10        | Liverpool MontevideoLiverpool Mon | 1 - 1 | WanderersWanderers |
| 24 Sep 22 | r10        | DanubioDanubio | 3 - 0 | CA River PlateCA River Plat |
| 24 Sep 22 | r10        | PeñarolPeñarol | 0 - 1 | Montevideo City TorqueMontevideo Ci |
| 25 Sep 22 | r10        | RentistasRentistas | 0 - 1 | Plaza ColoniaPlaza Colonia |
| 25 Sep 22 | r10        | Nacional MontevideoNacional Mont | 1 - 1 | Cerro Largo FCCerro Largo F |
| 26 Sep 22 | r10        | CerritoCerrito | 1 - 2 | Defensor SportingDefensor Spor |
| 26 Sep 22 | r10        | Albion FCAlbion FC | 1 - 1 | FenixFenix |
| |
| 30 Sep 22 | r11        | Cerro Largo FCCerro Largo F | 1 - 0 | DanubioDanubio |
| 01 Oct 22 | r11        | Plaza ColoniaPlaza Colonia | 1 - 3 | Liverpool MontevideoLiverpool Mon |
| 01 Oct 22 | r11        | Montevideo City TorqueMontevideo Ci | 0 - 1 | CerritoCerrito |
| 01 Oct 22 | r11        | FenixFenix | 1 - 1 | Nacional MontevideoNacional Mont |
| 02 Oct 22 | r11        | Defensor SportingDefensor Spor | 2 - 0 | Albion FCAlbion FC |
| 02 Oct 22 | r11        | CA River PlateCA River Plat | 0 - 0 | Deportivo MaldonadoDeportivo Mal |
| 02 Oct 22 | r11        | Boston RiverBoston River | 3 - 0 | RentistasRentistas |
| 02 Oct 22 | r11        | WanderersWanderers | 0 - 2 | PeñarolPeñarol |
| |
| 07 Oct 22 | r12        | Deportivo MaldonadoDeportivo Mal | 0 - 1 | Cerro Largo FCCerro Largo F |
| 08 Oct 22 | r12        | CerritoCerrito | 0 - 0 | Albion FCAlbion FC |
| 08 Oct 22 | r12        | RentistasRentistas | 0 - 5 | CA River PlateCA River Plat |
| 08 Oct 22 | r12        | DanubioDanubio | 1 - 1 | FenixFenix |
| 08 Oct 22 | r12        | Nacional MontevideoNacional Mont | 1 - 1 | Defensor SportingDefensor Spor |
| 09 Oct 22 | r12        | Montevideo City TorqueMontevideo Ci | 1 - 0 | WanderersWanderers |
| 09 Oct 22 | r12        | Liverpool MontevideoLiverpool Mon | 3 - 2 | Boston RiverBoston River |
| 09 Oct 22 | r12        | PeñarolPeñarol | 0 - 1 | Plaza ColoniaPlaza Colonia |
| |
| 11 Oct 22 | r13        | FenixFenix | 0 - 1 | Deportivo MaldonadoDeportivo Mal |
| 11 Oct 22 | r13        | Cerro Largo FCCerro Largo F | 2 - 1 | RentistasRentistas |
| 12 Oct 22 | r13        | Plaza ColoniaPlaza Colonia | 0 - 2 | Montevideo City TorqueMontevideo Ci |
| 12 Oct 22 | r13        | Boston RiverBoston River | 2 - 1 | PeñarolPeñarol |
| 13 Oct 22 | r13        | Defensor SportingDefensor Spor | 1 - 1 | DanubioDanubio |
| 13 Oct 22 | r13        | CA River PlateCA River Plat | 0 - 1 | Liverpool MontevideoLiverpool Mon |
| 13 Oct 22 | r13        | Albion FCAlbion FC | 0 - 1 | Nacional MontevideoNacional Mont |
| 14 Oct 22 | r13        | WanderersWanderers | 2 - 1 | CerritoCerrito |
| |
| 15 Oct 22 | r14        | RentistasRentistas | 1 - 3 | FenixFenix |
| 15 Oct 22 | r14        | Deportivo MaldonadoDeportivo Mal | 0 - 0 | Defensor SportingDefensor Spor |
| 16 Oct 22 | r14        | Liverpool MontevideoLiverpool Mon | 1 - 0 | Cerro Largo FCCerro Largo F |
| 16 Oct 22 | r14        | DanubioDanubio | 3 - 0 | Albion FCAlbion FC |
| 16 Oct 22 | r14        | PeñarolPeñarol | 1 - 1 | CA River PlateCA River Plat |
| 17 Oct 22 | r14        | Montevideo City TorqueMontevideo Ci | 0 - 2 | Boston RiverBoston River |
| 17 Oct 22 | r14        | WanderersWanderers | 2 - 1 | Plaza ColoniaPlaza Colonia |
| 18 Oct 22 | r14        | CerritoCerrito | 1 - 2 | Nacional MontevideoNacional Mont |
| |
| 21 Oct 22 | r15        | CA River PlateCA River Plat | 2 - 1 | Montevideo City TorqueMontevideo Ci |
| 22 Oct 22 | r15        | Defensor SportingDefensor Spor | 2 - 3 | RentistasRentistas |
| 22 Oct 22 | r15        | Cerro Largo FCCerro Largo F | 0 - 2 | PeñarolPeñarol |
| 23 Oct 22 | r15        | Plaza ColoniaPlaza Colonia | 1 - 3 | CerritoCerrito |
| 23 Oct 22 | r15        | FenixFenix | 0 - 3 | Liverpool MontevideoLiverpool Mon |
| 23 Oct 22 | r15        | Nacional MontevideoNacional Mont | 2 - 0 | DanubioDanubio |
| 24 Oct 22 | r15        | Boston RiverBoston River | 2 - 2 | WanderersWanderers |
| 24 Oct 22 | r15        | Albion FCAlbion FC | 1 - 3 | Deportivo MaldonadoDeportivo Mal |