| 16 May 21 | r01   | Deportivo MaldonadoDeportivo Mal | 2 - 4 | Liverpool MontevideoLiverpool Mon |
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| 24 May 21 | r02 | CA River PlateCA River Plat | 3 - 2 | Liverpool MontevideoLiverpool Mon |
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| 29 May 21 | r03 | Liverpool MontevideoLiverpool Mon | 3 - 0 | Cerro Largo FCCerro Largo F |
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| 04 Jun 21 | r04 | ProgresoProgreso | 1 - 3 | Liverpool MontevideoLiverpool Mon |
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| 11 Jun 21 | r05 | Liverpool MontevideoLiverpool Mon | 5 - 0 | Sud AméricaSud América |
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| 17 Jun 21 | r06 | Plaza ColoniaPlaza Colonia | 2 - 1 | Liverpool MontevideoLiverpool Mon |
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| 22 Jun 21 | r07 | Liverpool MontevideoLiverpool Mon | 5 - 2 | FenixFenix |
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| 27 Jun 21 | r08 | Boston RiverBoston River | 1 - 1 | Liverpool MontevideoLiverpool Mon |
| |
| 06 Jul 21 | r09  | Liverpool MontevideoLiverpool Mon | 2 - 1 | WanderersWanderers |
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| 12 Jul 21 | r10 | RentistasRentistas | 2 - 1 | Liverpool MontevideoLiverpool Mon |
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| 25 Jul 21 | r11 | Liverpool MontevideoLiverpool Mon | 3 - 3 | PeñarolPeñarol |
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| 01 Aug 21 | r12 | Montevideo City TorqueMontevideo Ci | 0 - 3 | Liverpool MontevideoLiverpool Mon |
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| 08 Aug 21 | r13 | Liverpool MontevideoLiverpool Mon | 2 - 2 | Villa EspañolaVilla Español |
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| 15 Aug 21 | r14 | Nacional MontevideoNacional Mont | 1 - 0 | Liverpool MontevideoLiverpool Mon |
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| 21 Aug 21 | r15 | Liverpool MontevideoLiverpool Mon | 3 - 0 | CerritoCerrito |
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| 13 Sep 21 | r01 | Liverpool MontevideoLiverpool Mon | 1 - 0 | Deportivo MaldonadoDeportivo Mal |
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| 19 Sep 21 | r02 | Liverpool MontevideoLiverpool Mon | 3 - 1 | CA River PlateCA River Plat |
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| 25 Sep 21 | r03 | Cerro Largo FCCerro Largo F | 3 - 0 | Liverpool MontevideoLiverpool Mon |
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| 03 Oct 21 | r04 | Liverpool MontevideoLiverpool Mon | 0 - 1 | ProgresoProgreso |
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| 10 Oct 21 | r05 | Sud AméricaSud América | 0 - 1 | Liverpool MontevideoLiverpool Mon |
| |
| 16 Oct 21 | r06 | Liverpool MontevideoLiverpool Mon | 0 - 1 | Plaza ColoniaPlaza Colonia |
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| 20 Oct 21 | r07 | FenixFenix | 1 - 1 | Liverpool MontevideoLiverpool Mon |
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| 24 Oct 21 | r08 | Liverpool MontevideoLiverpool Mon | 2 - 2 | Boston RiverBoston River |
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| 29 Oct 21 | r09 | WanderersWanderers | 1 - 0 | Liverpool MontevideoLiverpool Mon |
| |
| 03 Nov 21 | r10 | Liverpool MontevideoLiverpool Mon | 0 - 1 | RentistasRentistas |
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| 07 Nov 21 | r11 | PeñarolPeñarol | 1 - 0 | Liverpool MontevideoLiverpool Mon |
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| 13 Nov 21 | r12 | Liverpool MontevideoLiverpool Mon | 1 - 3 | Montevideo City TorqueMontevideo Ci |
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| 19 Nov 21 | r13 | Villa EspañolaVilla Español | 0 - 3 | Liverpool MontevideoLiverpool Mon |
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| 26 Nov 21 | r14 | Liverpool MontevideoLiverpool Mon | 2 - 2 | Nacional MontevideoNacional Mont |
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| 06 Dec 21 | r15 | CerritoCerrito | 2 - 1 | Liverpool MontevideoLiverpool Mon |
Team 2021 Schedules
Albion
Boston River
Central Español
Cerro
Cerro Largo
Danubio
Defensor Sporting
Deportivo Maldonado
Juventud Las Piedras
Liverpool Montevideo
Montevideo City Torque
Montevideo Wanderers
Nacional Montevideo
Peñarol
Progreso
Racing Montevideo
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