| 29 Oct 21 | r00  | Sheffield SharksSheffield Sha | 101 - 73 | Manchester GiantsManchester Gi |
| 31 Oct 21 | r00 | Cheshire PhoenixCheshire Phoe | 91 - 92 | Manchester GiantsManchester Gi |
| 05 Nov 21 | r00 | Manchester GiantsManchester Gi | 88 - 89 | Sheffield SharksSheffield Sha |
| 07 Nov 21 | r00 | Manchester GiantsManchester Gi | 99 - 80 | Glasgow RocksGlasgow Rocks |
| 12 Nov 21 | r00 | Manchester GiantsManchester Gi | 109 - 81 | Cheshire PhoenixCheshire Phoe |
| 17 Nov 21 | r00 | Plymouth RaidersPlymouth Raid | 93 - 99 | Manchester GiantsManchester Gi |
| 05 Dec 21 | r00 | London LionsLondon Lions | 107 - 80 | Manchester GiantsManchester Gi |
| 10 Dec 21 | r00 | Manchester GiantsManchester Gi | 94 - 79 | Glasgow RocksGlasgow Rocks |
| 30 Dec 21 | r00 | Manchester GiantsManchester Gi | 80 - 76 | Cheshire PhoenixCheshire Phoe |
| 02 Jan 22 | r00 | Manchester GiantsManchester Gi | 88 - 82 | Newcastle EaglesNewcastle Eag |
| 16 Jan 22 | r00 | Manchester GiantsManchester Gi | 77 - 84 | Plymouth RaidersPlymouth Raid |
| 21 Jan 22 | r00 | Newcastle EaglesNewcastle Eag | 113 - 111 | Manchester GiantsManchester Gi |
| 05 Feb 22 | r00 | Surrey ScorchersSurrey Scorch | 74 - 81 | Manchester GiantsManchester Gi |
| 11 Feb 22 | r00 | Leicester RidersLeicester Rid | 86 - 69 | Manchester GiantsManchester Gi |
| 13 Feb 22 | r00 | Plymouth RaidersPlymouth Raid | 77 - 76 | Manchester GiantsManchester Gi |
| 04 Mar 22 | r00 | Manchester GiantsManchester Gi | 58 - 81 | Bristol FlyersBristol Flyer |
| 06 Mar 22 | r00 | Manchester GiantsManchester Gi | 94 - 75 | Surrey ScorchersSurrey Scorch |
| 11 Mar 22 | r00 | Newcastle EaglesNewcastle Eag | 89 - 110 | Manchester GiantsManchester Gi |
| 13 Mar 22 | r00 | Manchester GiantsManchester Gi | 85 - 83 | Leicester RidersLeicester Rid |
| 17 Mar 22 | r00 | Manchester GiantsManchester Gi | 94 - 56 | London LionsLondon Lions |
| 27 Mar 22 | r00 | Glasgow RocksGlasgow Rocks | 100 - 99 | Manchester GiantsManchester Gi |
| 02 Apr 22 | r00 | Bristol FlyersBristol Flyer | 89 - 96 | Manchester GiantsManchester Gi |
| 08 Apr 22 | r00 | Leicester RidersLeicester Rid | 88 - 82 | Manchester GiantsManchester Gi |
| 10 Apr 22 | r00 | Manchester GiantsManchester Gi | 85 - 67 | Surrey ScorchersSurrey Scorch |
| 12 Apr 22 | r00 | Bristol FlyersBristol Flyer | 87 - 66 | Manchester GiantsManchester Gi |
| 22 Apr 22 | r00 | Sheffield SharksSheffield Sha | 91 - 86 | Manchester GiantsManchester Gi |
| 24 Apr 22 | r00 | Manchester GiantsManchester Gi | 80 - 90 | London LionsLondon Lions |
| 28 Apr 22 | r00 | Manchester GiantsManchester Gi | 91 - 79 | Bristol FlyersBristol Flyer |
| 30 Apr 22 | r00 | Bristol FlyersBristol Flyer | 94 - 80 | Manchester GiantsManchester Gi |
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