| 01 Oct 21 | r01        | ESSM Le PortelESSM Le Porte | 89 - 72 | Orléans Loiret BasketOrléans Loire |
| |
| 05 Oct 21 | r02        | ESSM Le PortelESSM Le Porte | 69 - 94 | Lyon-VilleurbanneLyon-Villeurb |
| |
| 09 Oct 21 | r03        | LimogesLimoges | 77 - 64 | ESSM Le PortelESSM Le Porte |
| |
| 15 Oct 21 | r04        | Châlons-ReimsChâlons-Reims | 106 - 73 | ESSM Le PortelESSM Le Porte |
| |
| 23 Oct 21 | r05        | ESSM Le PortelESSM Le Porte | 71 - 54 | Bourg-en-BresseBourg-en-Bres |
| |
| 29 Oct 21 | r06        | Fos Provence BasketFos Provence | 78 - 76 | ESSM Le PortelESSM Le Porte |
| |
| 05 Nov 21 | r07        | Gravelines-DunkerqueGravelines-Du | 101 - 58 | ESSM Le PortelESSM Le Porte |
| |
| 12 Nov 21 | r08        | ESSM Le PortelESSM Le Porte | 89 - 93 | Pau-Lacq-OrthezPau-Lacq-Orth |
| |
| 19 Nov 21 | r09        | Chorale Roanne BasketChorale Roann | 89 - 86 | ESSM Le PortelESSM Le Porte |
| |
| 10 Dec 21 | r11        | Paris BasketballParis Basketb | 62 - 86 | ESSM Le PortelESSM Le Porte |
| |
| 17 Dec 21 | r12        | ESSM Le PortelESSM Le Porte | 80 - 88 | Le Mans Sarthe BasketLe Mans Sarth |
| |
| 09 Jan 22 | r15        | AS Monaco BasketAS Monaco Bas | 79 - 67 | ESSM Le PortelESSM Le Porte |
| |
| 14 Jan 22 | r16        | ESSM Le PortelESSM Le Porte | 69 - 85 | CholetCholet |
| |
| 18 Jan 22 | r13        | NanterreNanterre | 98 - 82 | ESSM Le PortelESSM Le Porte |
| |
| 23 Jan 22 | r17        | DijonDijon | 86 - 72 | ESSM Le PortelESSM Le Porte |
| |
| 29 Jan 22 | r18        | StrasbourgStrasbourg | 79 - 82 | ESSM Le PortelESSM Le Porte |
| |
| 04 Feb 22 | r19        | ESSM Le PortelESSM Le Porte | 65 - 57 | Paris BasketballParis Basketb |
| |
| 11 Feb 22 | r20        | ESSM Le PortelESSM Le Porte | 70 - 65 | Chorale Roanne BasketChorale Roann |
| |
| 18 Feb 22 | r10        | ESSM Le PortelESSM Le Porte | 84 - 88 | StrasbourgStrasbourg |
| |
| 20 Feb 22 | r14        | ESSM Le PortelESSM Le Porte | 91 - 82 | Metropolitans 92Metropolitans |
| |
| 07 Mar 22 | r21        | Pau-Lacq-OrthezPau-Lacq-Orth | 75 - 70 | ESSM Le PortelESSM Le Porte |
| |
| 12 Mar 22 | r22        | ESSM Le PortelESSM Le Porte | 59 - 73 | LimogesLimoges |
| |
| 19 Mar 22 | r23        | Orléans Loiret BasketOrléans Loire | 71 - 76 | ESSM Le PortelESSM Le Porte |
| |
| 22 Mar 22 | r24        | ESSM Le PortelESSM Le Porte | 95 - 111 | Gravelines-DunkerqueGravelines-Du |
| |
| 29 Mar 22 | r25        | ESSM Le PortelESSM Le Porte | 87 - 71 | NanterreNanterre |
| |
| 03 Apr 22 | r26        | Lyon-VilleurbanneLyon-Villeurb | 85 - 65 | ESSM Le PortelESSM Le Porte |
| |
| 10 Apr 22 | r27        | ESSM Le PortelESSM Le Porte | 70 - 82 | AS Monaco BasketAS Monaco Bas |
| |
| 12 Apr 22 | r28        | Metropolitans 92Metropolitans | 99 - 94 | ESSM Le PortelESSM Le Porte |
| |
| 15 Apr 22 | r29        | ESSM Le PortelESSM Le Porte | 78 - 91 | DijonDijon |
| |
| 19 Apr 22 | r30        | CholetCholet | 84 - 90 | ESSM Le PortelESSM Le Porte |
| |
| 29 Apr 22 | r31        | ESSM Le PortelESSM Le Porte | 79 - 74 | Châlons-ReimsChâlons-Reims |
| |
| 03 May 22 | r32        | Le Mans Sarthe BasketLe Mans Sarth | 82 - 83 | ESSM Le PortelESSM Le Porte |
| |
| 10 May 22 | r33        | Bourg-en-BresseBourg-en-Bres | 83 - 86 | ESSM Le PortelESSM Le Porte |
| |
| 17 May 22 | r34        | ESSM Le PortelESSM Le Porte | 79 - 83 | Fos Provence BasketFos Provence |