| 07 Mar 25 | r01        | Wests TigersWests Tigers | 8 - 10 | Newcastle KnightsNewcastle Kni |
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| 13 Mar 25 | r02        | Newcastle KnightsNewcastle Kni | 26 - 12 | DolphinsDolphins |
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| 22 Mar 25 | r03        | Gold Coast TitansGold Coast Ti | 26 - 6 | Newcastle KnightsNewcastle Kni |
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| 06 Apr 25 | r05        | Canterbury Bankstown BullCanterbury Ba | 20 - 0 | Newcastle KnightsNewcastle Kni |
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| 13 Apr 25 | r06        | Newcastle KnightsNewcastle Kni | 4 - 20 | Wests TigersWests Tigers |
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| 20 Apr 25 | r07        | Newcastle KnightsNewcastle Kni | 14 - 34 | Cronulla SharksCronulla Shar |
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| 25 Apr 25 | r08        | New Zealand WarriorsNew Zealand W | 26 - 12 | Newcastle KnightsNewcastle Kni |
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| 03 May 25 | r09        | South Sydney RabbitohsSouth Sydney | 4 - 30 | Newcastle KnightsNewcastle Kni |
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| 09 May 25 | r10        | Newcastle KnightsNewcastle Kni | 20 - 24 | Gold Coast TitansGold Coast Ti |
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| 16 May 25 | r11        | Newcastle KnightsNewcastle Kni | 6 - 28 | Parramatta EelsParramatta Ee |
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| 24 May 25 | r12        | Penrith PanthersPenrith Panth | 6 - 25 | Newcastle KnightsNewcastle Kni |
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| 30 May 25 | r13        | St. George Illawara DragoSt. George Il | 20 - 6 | Newcastle KnightsNewcastle Kni |
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| 05 Jun 25 | r14        | Newcastle KnightsNewcastle Kni | 26 - 22 | Manly Sea EaglesManly Sea Eag |
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| 14 Jun 25 | r15        | Newcastle KnightsNewcastle Kni | 8 - 12 | Sydney RoostersSydney Rooste |
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| 21 Jun 25 | r16        | DolphinsDolphins | 20 - 26 | Newcastle KnightsNewcastle Kni |
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| 27 Jun 25 | r17        | Newcastle KnightsNewcastle Kni | 18 - 22 | Canberra RaidersCanberra Raid |
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| 12 Jul 25 | r19        | Newcastle KnightsNewcastle Kni | 14 - 32 | Melbourne StormMelbourne Sto |
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| 20 Jul 25 | r20        | Newcastle KnightsNewcastle Kni | 15 - 20 | New Zealand WarriorsNew Zealand W |
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| 27 Jul 25 | r21        | Canberra RaidersCanberra Raid | 44 - 18 | Newcastle KnightsNewcastle Kni |
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| 08 Aug 25 | r23        | Newcastle KnightsNewcastle Kni | 12 - 48 | Penrith PanthersPenrith Panth |
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| 17 Aug 25 | r24        | North Queensland CowboysNorth Queensl | 38 - 4 | Newcastle KnightsNewcastle Kni |
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| 24 Aug 25 | r25        | Newcastle KnightsNewcastle Kni | 12 - 46 | Brisbane BroncosBrisbane Bron |
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| 31 Aug 25 | r26        | Cronulla SharksCronulla Shar | 40 - 16 | Newcastle KnightsNewcastle Kni |
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| 07 Sep 25 | r27        | Parramatta EelsParramatta Ee | 66 - 10 | Newcastle KnightsNewcastle Kni |