| 02 Mar 25 | r01        | Penrith PanthersPenrith Panth | 28 - 22 | Cronulla SharksCronulla Shar |
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| 14 Mar 25 | r02        | Penrith PanthersPenrith Panth | 32 - 38 | Sydney RoostersSydney Rooste |
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| 20 Mar 25 | r03        | Melbourne StormMelbourne Sto | 30 - 24 | Penrith PanthersPenrith Panth |
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| 27 Mar 25 | r04        | South Sydney RabbitohsSouth Sydney | 28 - 18 | Penrith PanthersPenrith Panth |
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| 04 Apr 25 | r05        | Penrith PanthersPenrith Panth | 18 - 22 | North Queensland CowboysNorth Queensl |
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| 10 Apr 25 | r06        | DolphinsDolphins | 30 - 12 | Penrith PanthersPenrith Panth |
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| 19 Apr 25 | r07        | Sydney RoostersSydney Rooste | 12 - 40 | Penrith PanthersPenrith Panth |
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| 26 Apr 25 | r08        | Penrith PanthersPenrith Panth | 10 - 26 | Manly Sea EaglesManly Sea Eag |
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| 04 May 25 | r09        | Penrith PanthersPenrith Panth | 32 - 8 | Brisbane BroncosBrisbane Bron |
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| 10 May 25 | r10        | North Queensland CowboysNorth Queensl | 30 - 30 | Penrith PanthersPenrith Panth |
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| 24 May 25 | r12        | Penrith PanthersPenrith Panth | 6 - 25 | Newcastle KnightsNewcastle Kni |
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| 01 Jun 25 | r13        | Penrith PanthersPenrith Panth | 18 - 10 | Parramatta EelsParramatta Ee |
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| 08 Jun 25 | r14        | Wests TigersWests Tigers | 14 - 18 | Penrith PanthersPenrith Panth |
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| 21 Jun 25 | r16        | New Zealand WarriorsNew Zealand W | 18 - 28 | Penrith PanthersPenrith Panth |
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| 26 Jun 25 | r17        | Penrith PanthersPenrith Panth | 8 - 6 | Canterbury Bankstown BullCanterbury Ba |
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| 13 Jul 25 | r19        | Parramatta EelsParramatta Ee | 10 - 32 | Penrith PanthersPenrith Panth |
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| 18 Jul 25 | r20        | Penrith PanthersPenrith Panth | 30 - 10 | South Sydney RabbitohsSouth Sydney |
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| 26 Jul 25 | r21        | Penrith PanthersPenrith Panth | 36 - 2 | Wests TigersWests Tigers |
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| 02 Aug 25 | r22        | Gold Coast TitansGold Coast Ti | 26 - 30 | Penrith PanthersPenrith Panth |
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| 08 Aug 25 | r23        | Newcastle KnightsNewcastle Kni | 12 - 48 | Penrith PanthersPenrith Panth |
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| 14 Aug 25 | r24        | Penrith PanthersPenrith Panth | 18 - 22 | Melbourne StormMelbourne Sto |
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| 22 Aug 25 | r25        | Penrith PanthersPenrith Panth | 16 - 20 | Canberra RaidersCanberra Raid |
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| 28 Aug 25 | r26        | Canterbury Bankstown BullCanterbury Ba | 28 - 4 | Penrith PanthersPenrith Panth |
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| 06 Sep 25 | r27        | St. George Illawara DragoSt. George Il | 20 - 40 | Penrith PanthersPenrith Panth |
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| 13 Sep 25 | Playoff        | New Zealand WarriorsNew Zealand W | 8 - 24 | Penrith PanthersPenrith Panth |
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| 21 Sep 25 | QF        | Canterbury Bankstown BullCanterbury Ba | 26 - 46 | Penrith PanthersPenrith Panth |
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| 28 Sep 25 | SF        | Brisbane BroncosBrisbane Bron | 16 - 14 | Penrith PanthersPenrith Panth |