| 10 Mar 22 | r01        | Penrith PanthersPenrith Panth | 28 - 6 | Manly Sea EaglesManly Sea Eag |
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| 18 Mar 22 | r02        | St. George Illawara DragoSt. George Il | 16 - 20 | Penrith PanthersPenrith Panth |
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| 26 Mar 22 | r03        | Penrith PanthersPenrith Panth | 38 - 20 | Newcastle KnightsNewcastle Kni |
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| 01 Apr 22 | r04        | Penrith PanthersPenrith Panth | 26 - 12 | South Sydney RabbitohsSouth Sydney |
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| 10 Apr 22 | r05        | Canterbury Bankstown BullCanterbury Ba | 12 - 32 | Penrith PanthersPenrith Panth |
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| 15 Apr 22 | r06        | Penrith PanthersPenrith Panth | 40 - 12 | Brisbane BroncosBrisbane Bron |
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| 24 Apr 22 | r07        | Penrith PanthersPenrith Panth | 36 - 6 | Canberra RaidersCanberra Raid |
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| 29 Apr 22 | r08        | Gold Coast TitansGold Coast Ti | 4 - 18 | Penrith PanthersPenrith Panth |
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| 06 May 22 | r09        | Penrith PanthersPenrith Panth | 20 - 22 | Parramatta EelsParramatta Ee |
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| 14 May 22 | r10        | Melbourne StormMelbourne Sto | 6 - 32 | Penrith PanthersPenrith Panth |
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| 21 May 22 | r11        | Sydney RoostersSydney Rooste | 12 - 32 | Penrith PanthersPenrith Panth |
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| 27 May 22 | r12        | Penrith PanthersPenrith Panth | 22 - 0 | North Queensland CowboysNorth Queensl |
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| 03 Jun 22 | r13        | Penrith PanthersPenrith Panth | 30 - 18 | Canterbury Bankstown BullCanterbury Ba |
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| 12 Jun 22 | r14        | Newcastle KnightsNewcastle Kni | 6 - 42 | Penrith PanthersPenrith Panth |
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| 18 Jun 22 | r15        | New Zealand WarriorsNew Zealand W | 6 - 40 | Penrith PanthersPenrith Panth |
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| 01 Jul 22 | r16        | Penrith PanthersPenrith Panth | 26 - 18 | Sydney RoostersSydney Rooste |
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| 17 Jul 22 | r18        | Wests TigersWests Tigers | 16 - 18 | Penrith PanthersPenrith Panth |
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| 23 Jul 22 | r19        | Penrith PanthersPenrith Panth | 20 - 10 | Cronulla SharksCronulla Shar |
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| 29 Jul 22 | r20        | Parramatta EelsParramatta Ee | 34 - 10 | Penrith PanthersPenrith Panth |
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| 06 Aug 22 | r21        | Canberra RaidersCanberra Raid | 6 - 26 | Penrith PanthersPenrith Panth |
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| 11 Aug 22 | r20        | Penrith PanthersPenrith Panth | 0 - 16 | Melbourne StormMelbourne Sto |
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| 18 Aug 22 | r23        | South Sydney RabbitohsSouth Sydney | 22 - 26 | Penrith PanthersPenrith Panth |
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| 26 Aug 22 | r24        | Penrith PanthersPenrith Panth | 46 - 12 | New Zealand WarriorsNew Zealand W |
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| 03 Sep 22 | r25        | North Queensland CowboysNorth Queensl | 38 - 8 | Penrith PanthersPenrith Panth |
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| 09 Sep 22 | Playoff        | Penrith PanthersPenrith Panth | 27 - 8 | Parramatta EelsParramatta Ee |
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| 24 Sep 22 | SF        | Penrith PanthersPenrith Panth | 32 - 12 | South Sydney RabbitohsSouth Sydney |
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| 02 Oct 22 | Final        | Penrith PanthersPenrith Panth | 28 - 12 | Parramatta EelsParramatta Ee |