| 13 Mar 22 | r01        | Parramatta EelsParramatta Ee | 32 - 28 | Gold Coast TitansGold Coast Ti |
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| 19 Mar 22 | r02        | Gold Coast TitansGold Coast Ti | 20 - 18 | New Zealand WarriorsNew Zealand W |
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| 26 Mar 22 | r03        | Canberra RaidersCanberra Raid | 24 - 22 | Gold Coast TitansGold Coast Ti |
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| 31 Mar 22 | r04        | Gold Coast TitansGold Coast Ti | 8 - 6 | Wests TigersWests Tigers |
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| 09 Apr 22 | r05        | Gold Coast TitansGold Coast Ti | 20 - 26 | Parramatta EelsParramatta Ee |
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| 16 Apr 22 | r06        | Manly Sea EaglesManly Sea Eag | 26 - 18 | Gold Coast TitansGold Coast Ti |
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| 23 Apr 22 | r07        | North Queensland CowboysNorth Queensl | 30 - 4 | Gold Coast TitansGold Coast Ti |
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| 29 Apr 22 | r08        | Gold Coast TitansGold Coast Ti | 4 - 18 | Penrith PanthersPenrith Panth |
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| 07 May 22 | r09        | Sydney RoostersSydney Rooste | 44 - 16 | Gold Coast TitansGold Coast Ti |
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| 14 May 22 | r10        | Gold Coast TitansGold Coast Ti | 20 - 16 | St. George Illawara DragoSt. George Il |
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| 22 May 22 | r11        | Gold Coast TitansGold Coast Ti | 18 - 25 | Cronulla SharksCronulla Shar |
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| 27 May 22 | r12        | Brisbane BroncosBrisbane Bron | 35 - 24 | Gold Coast TitansGold Coast Ti |
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| 02 Jun 22 | r13        | Gold Coast TitansGold Coast Ti | 6 - 32 | North Queensland CowboysNorth Queensl |
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| 11 Jun 22 | r14        | Gold Coast TitansGold Coast Ti | 16 - 30 | South Sydney RabbitohsSouth Sydney |
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| 18 Jun 22 | r15        | Cronulla SharksCronulla Shar | 18 - 10 | Gold Coast TitansGold Coast Ti |
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| 01 Jul 22 | r16        | Newcastle KnightsNewcastle Kni | 38 - 12 | Gold Coast TitansGold Coast Ti |
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| 16 Jul 22 | r18        | Gold Coast TitansGold Coast Ti | 12 - 16 | Brisbane BroncosBrisbane Bron |
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| 24 Jul 22 | r19        | Canterbury Bankstown BullCanterbury Ba | 36 - 26 | Gold Coast TitansGold Coast Ti |
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| 30 Jul 22 | r20        | Gold Coast TitansGold Coast Ti | 24 - 36 | Canberra RaidersCanberra Raid |
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| 05 Aug 22 | r21        | Melbourne StormMelbourne Sto | 32 - 14 | Gold Coast TitansGold Coast Ti |
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| 14 Aug 22 | r20        | Gold Coast TitansGold Coast Ti | 44 - 24 | Manly Sea EaglesManly Sea Eag |
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| 21 Aug 22 | r23        | St. George Illawara DragoSt. George Il | 46 - 26 | Gold Coast TitansGold Coast Ti |
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| 28 Aug 22 | r24        | Gold Coast TitansGold Coast Ti | 36 - 26 | Newcastle KnightsNewcastle Kni |
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| 03 Sep 22 | r25        | New Zealand WarriorsNew Zealand W | 26 - 27 | Gold Coast TitansGold Coast Ti |