| 07 Apr 22 | r05        | Newcastle KnightsNewcastle Kni | 6 - 30 | Manly Sea EaglesManly Sea Eag |
| 08 Apr 22 | r05        | Brisbane BroncosBrisbane Bron | 20 - 24 | Sydney RoostersSydney Rooste |
| 08 Apr 22 | r05        | New Zealand WarriorsNew Zealand W | 25 - 24 | North Queensland CowboysNorth Queensl |
| 09 Apr 22 | r05        | Canberra RaidersCanberra Raid | 16 - 30 | Melbourne StormMelbourne Sto |
| 09 Apr 22 | r05        | South Sydney RabbitohsSouth Sydney | 24 - 12 | St. George Illawara DragoSt. George Il |
| 09 Apr 22 | r05        | Gold Coast TitansGold Coast Ti | 20 - 26 | Parramatta EelsParramatta Ee |
| 10 Apr 22 | r05        | Cronulla SharksCronulla Shar | 30 - 4 | Wests TigersWests Tigers |
| 10 Apr 22 | r05        | Canterbury Bankstown BullCanterbury Ba | 12 - 32 | Penrith PanthersPenrith Panth |