| 12 Mar 21 | r01        | Newcastle Knights Newcastle Kni | 32 - 16 | Canterbury Bankstown BullCanterbury Ba |
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| 19 Mar 21 | r02        | New Zealand WarriorsNew Zealand W | 16 - 20 | Newcastle Knights Newcastle Kni |
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| 28 Mar 21 | r03        | Newcastle Knights Newcastle Kni | 20 - 24 | Wests TigersWests Tigers |
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| 04 Apr 21 | r04        | Newcastle Knights Newcastle Kni | 13 - 22 | St. George Illawara DragoSt. George Il |
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| 10 Apr 21 | r05        | Gold Coast TitansGold Coast Ti | 42 - 16 | Newcastle Knights Newcastle Kni |
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| 16 Apr 21 | r06        | Newcastle Knights Newcastle Kni | 26 - 22 | Cronulla SharksCronulla Shar |
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| 22 Apr 21 | r07        | Penrith PanthersPenrith Panth | 24 - 6 | Newcastle Knights Newcastle Kni |
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| 01 May 21 | r08        | Newcastle Knights Newcastle Kni | 4 - 38 | Sydney RoostersSydney Rooste |
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| 08 May 21 | r09        | Canberra RaidersCanberra Raid | 16 - 24 | Newcastle Knights Newcastle Kni |
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| 14 May 21 | r10        | Wests TigersWests Tigers | 36 - 18 | Newcastle Knights Newcastle Kni |
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| 20 May 21 | r11        | North Queensland CowboysNorth Queensl | 36 - 20 | Newcastle Knights Newcastle Kni |
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| 30 May 21 | r12        | Newcastle Knights Newcastle Kni | 18 - 10 | Manly Sea EaglesManly Sea Eag |
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| 06 Jun 21 | r13        | Newcastle Knights Newcastle Kni | 4 - 40 | Parramatta EelsParramatta Ee |
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| 12 Jun 21 | r14        | South Sydney RabbitohsSouth Sydney | 24 - 10 | Newcastle Knights Newcastle Kni |
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| 19 Jun 21 | r15        | Newcastle Knights Newcastle Kni | 10 - 6 | New Zealand WarriorsNew Zealand W |
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| 03 Jul 21 | r16        | Newcastle Knights Newcastle Kni | 38 - 0 | North Queensland CowboysNorth Queensl |
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| 17 Jul 21 | r18        | Melbourne StormMelbourne Sto | 48 - 4 | Newcastle Knights Newcastle Kni |
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| 23 Jul 21 | r19        | Sydney RoostersSydney Rooste | 28 - 8 | Newcastle Knights Newcastle Kni |
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| 31 Jul 21 | r20        | Newcastle Knights Newcastle Kni | 34 - 24 | Canberra RaidersCanberra Raid |
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| 05 Aug 21 | r21        | Newcastle Knights Newcastle Kni | 28 - 20 | Brisbane BroncosBrisbane Bron |
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| 15 Aug 21 | r22        | Cronulla SharksCronulla Shar | 14 - 16 | Newcastle Knights Newcastle Kni |
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| 21 Aug 21 | r23        | Canterbury Bankstown BullCanterbury Ba | 16 - 22 | Newcastle Knights Newcastle Kni |
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| 26 Aug 21 | r24        | Newcastle Knights Newcastle Kni | 15 - 14 | Gold Coast TitansGold Coast Ti |
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| 04 Sep 21 | r25        | Brisbane BroncosBrisbane Bron | 35 - 22 | Newcastle Knights Newcastle Kni |
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| 12 Sep 21 | Playoff        | Parramatta EelsParramatta Ee | 28 - 20 | Newcastle KnightsNewcastle Kni |