| 13 Mar 21 | r01        | Penrith PanthersPenrith Panth | 24 - 0 | North Queensland CowboysNorth Queensl |
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| 20 Mar 21 | r02        | Canterbury Bankstown BullCanterbury Ba | 0 - 28 | Penrith PanthersPenrith Panth |
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| 25 Mar 21 | r03        | Penrith PanthersPenrith Panth | 12 - 10 | Melbourne StormMelbourne Sto |
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| 01 Apr 21 | r04        | Manly Sea EaglesManly Sea Eag | 6 - 46 | Penrith PanthersPenrith Panth |
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| 09 Apr 21 | r05        | Penrith PanthersPenrith Panth | 30 - 10 | Canberra RaidersCanberra Raid |
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| 15 Apr 21 | r06        | Brisbane BroncosBrisbane Bron | 12 - 20 | Penrith PanthersPenrith Panth |
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| 22 Apr 21 | r07        | Penrith PanthersPenrith Panth | 24 - 6 | Newcastle Knights Newcastle Kni |
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| 01 May 21 | r08        | Penrith PanthersPenrith Panth | 28 - 16 | Manly Sea EaglesManly Sea Eag |
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| 07 May 21 | r09        | Penrith PanthersPenrith Panth | 48 - 0 | Cronulla SharksCronulla Shar |
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| 16 May 21 | r10        | Gold Coast TitansGold Coast Ti | 12 - 48 | Penrith PanthersPenrith Panth |
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| 23 May 21 | r11        | South Sydney RabbitohsSouth Sydney | 12 - 56 | Penrith PanthersPenrith Panth |
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| 29 May 21 | r12        | Penrith PanthersPenrith Panth | 30 - 4 | Canterbury Bankstown BullCanterbury Ba |
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| 04 Jun 21 | r13        | Wests TigersWests Tigers | 26 - 6 | Penrith PanthersPenrith Panth |
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| 11 Jun 21 | r14        | Cronulla SharksCronulla Shar | 19 - 18 | Penrith PanthersPenrith Panth |
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| 18 Jun 21 | r15        | Penrith PanthersPenrith Panth | 38 - 12 | Sydney RoostersSydney Rooste |
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| 02 Jul 21 | r16        | Penrith PanthersPenrith Panth | 13 - 12 | Parramatta EelsParramatta Ee |
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| 18 Jul 21 | r18        | New Zealand WarriorsNew Zealand W | 16 - 30 | Penrith PanthersPenrith Panth |
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| 24 Jul 21 | r19        | Penrith PanthersPenrith Panth | 18 - 12 | Brisbane BroncosBrisbane Bron |
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| 31 Jul 21 | r20        | Melbourne StormMelbourne Sto | 37 - 10 | Penrith PanthersPenrith Panth |
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| 07 Aug 21 | r21        | Sydney RoostersSydney Rooste | 14 - 20 | Penrith PanthersPenrith Panth |
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| 13 Aug 21 | r22        | St. George Illawara DragoSt. George Il | 16 - 34 | Penrith PanthersPenrith Panth |
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| 20 Aug 21 | r23        | Penrith PanthersPenrith Panth | 25 - 12 | South Sydney RabbitohsSouth Sydney |
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| 29 Aug 21 | r24        | Penrith PanthersPenrith Panth | 30 - 16 | Wests TigersWests Tigers |
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| 03 Sep 21 | r25        | Parramatta EelsParramatta Ee | 6 - 40 | Penrith PanthersPenrith Panth |
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| 11 Sep 21 | Playoff        | Penrith PanthersPenrith Panth | 10 - 16 | South Sydney RabbitohsSouth Sydney |
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| 18 Sep 21 | QF        | Penrith PanthersPenrith Panth | 8 - 6 | Parramatta EelsParramatta Ee |
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| 25 Sep 21 | SF        | Melbourne StormMelbourne Sto | 6 - 10 | Penrith PanthersPenrith Panth |
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| 03 Oct 21 | Final        | Penrith PanthersPenrith Panth | 14 - 12 | South Sydney RabbitohsSouth Sydney |