| 13 Mar 21 | r01        | New Zealand WarriorsNew Zealand W | 19 - 6 | Gold Coast TitansGold Coast Ti |
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| 19 Mar 21 | r02        | Gold Coast TitansGold Coast Ti | 28 - 16 | Brisbane BroncosBrisbane Bron |
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| 28 Mar 21 | r03        | North Queensland CowboysNorth Queensl | 8 - 44 | Gold Coast TitansGold Coast Ti |
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| 03 Apr 21 | r04        | Gold Coast TitansGold Coast Ti | 4 - 20 | Canberra RaidersCanberra Raid |
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| 10 Apr 21 | r05        | Gold Coast TitansGold Coast Ti | 42 - 16 | Newcastle Knights Newcastle Kni |
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| 17 Apr 21 | r06        | Manly Sea EaglesManly Sea Eag | 36 - 0 | Gold Coast TitansGold Coast Ti |
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| 23 Apr 21 | r07        | Gold Coast TitansGold Coast Ti | 30 - 40 | South Sydney RabbitohsSouth Sydney |
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| 30 Apr 21 | r08        | Brisbane BroncosBrisbane Bron | 36 - 28 | Gold Coast TitansGold Coast Ti |
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| 08 May 21 | r09        | Wests TigersWests Tigers | 28 - 36 | Gold Coast TitansGold Coast Ti |
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| 16 May 21 | r10        | Gold Coast TitansGold Coast Ti | 12 - 48 | Penrith PanthersPenrith Panth |
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| 22 May 21 | r11        | Gold Coast TitansGold Coast Ti | 30 - 20 | Canterbury Bankstown BullCanterbury Ba |
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| 30 May 21 | r12        | Cronulla SharksCronulla Shar | 38 - 10 | Gold Coast TitansGold Coast Ti |
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| 05 Jun 21 | r13        | Melbourne StormMelbourne Sto | 20 - 14 | Gold Coast TitansGold Coast Ti |
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| 12 Jun 21 | r14        | Gold Coast TitansGold Coast Ti | 34 - 35 | Sydney RoostersSydney Rooste |
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| 20 Jun 21 | r15        | Gold Coast TitansGold Coast Ti | 24 - 56 | Manly Sea EaglesManly Sea Eag |
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| 03 Jul 21 | r16        | Canberra RaidersCanberra Raid | 6 - 44 | Gold Coast TitansGold Coast Ti |
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| 16 Jul 21 | r18        | Gold Coast TitansGold Coast Ti | 8 - 26 | Parramatta EelsParramatta Ee |
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| 25 Jul 21 | r19        | St. George Illawara DragoSt. George Il | 10 - 32 | Gold Coast TitansGold Coast Ti |
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| 01 Aug 21 | r20        | Canterbury Bankstown BullCanterbury Ba | 6 - 34 | Gold Coast TitansGold Coast Ti |
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| 08 Aug 21 | r21        | Gold Coast TitansGold Coast Ti | 36 - 14 | North Queensland CowboysNorth Queensl |
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| 14 Aug 21 | r22        | South Sydney RabbitohsSouth Sydney | 36 - 6 | Gold Coast TitansGold Coast Ti |
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| 19 Aug 21 | r23        | Gold Coast TitansGold Coast Ti | 20 - 34 | Melbourne StormMelbourne Sto |
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| 26 Aug 21 | r24        | Newcastle Knights Newcastle Kni | 15 - 14 | Gold Coast TitansGold Coast Ti |
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| 05 Sep 21 | r25        | Gold Coast TitansGold Coast Ti | 44 - 0 | New Zealand WarriorsNew Zealand W |
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| 11 Sep 21 | Playoff        | Sydney RoostersSydney Rooste | 25 - 24 | Gold Coast TitansGold Coast Ti |