| 12 Mar 21 | r01        | Brisbane BroncosBrisbane Bron | 16 - 24 | Parramatta EelsParramatta Ee |
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| 19 Mar 21 | r02        | Gold Coast TitansGold Coast Ti | 28 - 16 | Brisbane BroncosBrisbane Bron |
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| 27 Mar 21 | r03        | Brisbane BroncosBrisbane Bron | 24 - 0 | Canterbury Bankstown BullCanterbury Ba |
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| 02 Apr 21 | r04        | Melbourne StormMelbourne Sto | 40 - 6 | Brisbane BroncosBrisbane Bron |
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| 08 Apr 21 | r05        | South Sydney RabbitohsSouth Sydney | 35 - 6 | Brisbane BroncosBrisbane Bron |
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| 15 Apr 21 | r06        | Brisbane BroncosBrisbane Bron | 12 - 20 | Penrith PanthersPenrith Panth |
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| 23 Apr 21 | r07        | Parramatta EelsParramatta Ee | 46 - 4 | Brisbane BroncosBrisbane Bron |
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| 30 Apr 21 | r08        | Brisbane BroncosBrisbane Bron | 36 - 28 | Gold Coast TitansGold Coast Ti |
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| 08 May 21 | r09        | North Queensland CowboysNorth Queensl | 19 - 18 | Brisbane BroncosBrisbane Bron |
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| 14 May 21 | r10        | Manly Sea EaglesManly Sea Eag | 50 - 6 | Brisbane BroncosBrisbane Bron |
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| 22 May 21 | r11        | Sydney RoostersSydney Rooste | 16 - 34 | Brisbane BroncosBrisbane Bron |
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| 27 May 21 | r12        | Brisbane BroncosBrisbane Bron | 12 - 40 | Melbourne StormMelbourne Sto |
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| 03 Jun 21 | r13        | St. George Illawara DragoSt. George Il | 52 - 24 | Brisbane BroncosBrisbane Bron |
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| 12 Jun 21 | r14        | Canberra RaidersCanberra Raid | 38 - 16 | Brisbane BroncosBrisbane Bron |
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| 17 Jun 21 | r15        | Brisbane BroncosBrisbane Bron | 0 - 46 | South Sydney RabbitohsSouth Sydney |
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| 04 Jul 21 | r16        | Brisbane BroncosBrisbane Bron | 26 - 18 | Cronulla SharksCronulla Shar |
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| 18 Jul 21 | r18        | Brisbane BroncosBrisbane Bron | 24 - 42 | Wests TigersWests Tigers |
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| 24 Jul 21 | r19        | Penrith PanthersPenrith Panth | 18 - 12 | Brisbane BroncosBrisbane Bron |
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| 30 Jul 21 | r20        | Brisbane BroncosBrisbane Bron | 37 - 18 | North Queensland CowboysNorth Queensl |
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| 05 Aug 21 | r21        | Newcastle Knights Newcastle Kni | 28 - 20 | Brisbane BroncosBrisbane Bron |
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| 13 Aug 21 | r22        | Brisbane BroncosBrisbane Bron | 20 - 21 | Sydney RoostersSydney Rooste |
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| 22 Aug 21 | r23        | Brisbane BroncosBrisbane Bron | 24 - 22 | New Zealand WarriorsNew Zealand W |
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| 28 Aug 21 | r24        | Cronulla SharksCronulla Shar | 24 - 16 | Brisbane BroncosBrisbane Bron |
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| 04 Sep 21 | r25        | Brisbane BroncosBrisbane Bron | 35 - 22 | Newcastle Knights Newcastle Kni |