| 02 Sep 21 | r25        | Canberra RaidersCanberra Raid | 16 - 40 | Sydney RoostersSydney Rooste |
| 03 Sep 21 | r25        | Cronulla SharksCronulla Shar | 16 - 28 | Melbourne StormMelbourne Sto |
| 03 Sep 21 | r25        | Parramatta EelsParramatta Ee | 6 - 40 | Penrith PanthersPenrith Panth |
| 04 Sep 21 | r25        | Brisbane BroncosBrisbane Bron | 35 - 22 | Newcastle Knights Newcastle Kni |
| 04 Sep 21 | r25        | North Queensland CowboysNorth Queensl | 18 - 46 | Manly Sea EaglesManly Sea Eag |
| 04 Sep 21 | r25        | South Sydney RabbitohsSouth Sydney | 20 - 16 | St. George Illawara DragoSt. George Il |
| 05 Sep 21 | r25        | Gold Coast TitansGold Coast Ti | 44 - 0 | New Zealand WarriorsNew Zealand W |
| 05 Sep 21 | r25        | Wests TigersWests Tigers | 0 - 38 | Canterbury Bankstown BullCanterbury Ba |