| 08 Apr 21 | r05        | South Sydney RabbitohsSouth Sydney | 35 - 6 | Brisbane BroncosBrisbane Bron |
| 09 Apr 21 | r05        | New Zealand WarriorsNew Zealand W | 12 - 13 | Manly Sea EaglesManly Sea Eag |
| 09 Apr 21 | r05        | Penrith PanthersPenrith Panth | 30 - 10 | Canberra RaidersCanberra Raid |
| 10 Apr 21 | r05        | Gold Coast TitansGold Coast Ti | 42 - 16 | Newcastle Knights Newcastle Kni |
| 10 Apr 21 | r05        | Canterbury Bankstown BullCanterbury Ba | 18 - 52 | Melbourne StormMelbourne Sto |
| 10 Apr 21 | r05        | Sydney RoostersSydney Rooste | 26 - 18 | Cronulla SharksCronulla Shar |
| 11 Apr 21 | r05        | Wests TigersWests Tigers | 30 - 34 | North Queensland CowboysNorth Queensl |
| 11 Apr 21 | r05        | Parramatta EelsParramatta Ee | 12 - 26 | St. George Illawara DragoSt. George Il |