| 11 Mar 18 | r01        | Penrith PanthersPenrith Panth | 24 - 14 | Parramatta EelsParramatta Ee |
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| 17 Mar 18 | r02        | Penrith PanthersPenrith Panth | 18 - 14 | South Sydney RabbitohsSouth Sydney |
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| 23 Mar 18 | r03        | Canterbury Bankstown BullCanterbury Ba | 20 - 18 | Penrith PanthersPenrith Panth |
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| 29 Mar 18 | r04        | North Queensland Cowboys North Queensl | 14 - 33 | Penrith PanthersPenrith Panth |
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| 08 Apr 18 | r05        | Parramatta EelsParramatta Ee | 6 - 12 | Penrith PanthersPenrith Panth |
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| 15 Apr 18 | r06        | Penrith PanthersPenrith Panth | 35 - 12 | Gold Coast TitansGold Coast Ti |
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| 22 Apr 18 | r07        | Cronulla SharksCronulla Shar | 26 - 22 | Penrith PanthersPenrith Panth |
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| 27 Apr 18 | r08        | Penrith PanthersPenrith Panth | 22 - 14 | Canterbury Bankstown BullCanterbury Ba |
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| 04 May 18 | r09        | Penrith PanthersPenrith Panth | 20 - 26 | North Queensland Cowboys North Queensl |
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| 11 May 18 | r10        | Newcastle Knights Newcastle Kni | 18 - 29 | Penrith PanthersPenrith Panth |
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| 17 May 18 | r11        | Penrith PanthersPenrith Panth | 16 - 2 | Wests TigersWests Tigers |
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| 26 May 18 | r12        | Penrith PanthersPenrith Panth | 28 - 2 | St. George Illawara DragoSt. George Il |
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| 08 Jun 18 | r14        | Canberra RaidersCanberra Raid | 22 - 23 | Penrith PanthersPenrith Panth |
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| 15 Jun 18 | r15        | Sydney RoostersSydney Rooste | 32 - 6 | Penrith PanthersPenrith Panth |
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| 30 Jun 18 | r16        | Penrith PanthersPenrith Panth | 10 - 18 | Manly Sea EaglesManly Sea Eag |
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| 06 Jul 18 | r17        | Penrith PanthersPenrith Panth | 36 - 4 | New Zealand WarriorsNew Zealand W |
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| 13 Jul 18 | r18        | Penrith PanthersPenrith Panth | 12 - 24 | Cronulla SharksCronulla Shar |
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| 20 Jul 18 | r19        | Brisbane BroncosBrisbane Bron | 50 - 18 | Penrith PanthersPenrith Panth |
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| 28 Jul 18 | r20        | Manly Sea EaglesManly Sea Eag | 24 - 28 | Penrith PanthersPenrith Panth |
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| 05 Aug 18 | r21        | Penrith PanthersPenrith Panth | 40 - 31 | Canberra RaidersCanberra Raid |
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| 11 Aug 18 | r22        | Gold Coast TitansGold Coast Ti | 16 - 17 | Penrith PanthersPenrith Panth |
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| 18 Aug 18 | r23        | Penrith PanthersPenrith Panth | 12 - 20 | Newcastle Knights Newcastle Kni |
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| 24 Aug 18 | r24        | New Zealand WarriorsNew Zealand W | 36 - 16 | Penrith PanthersPenrith Panth |
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| 31 Aug 18 | r25        | Melbourne StormMelbourne Sto | 16 - 22 | Penrith PanthersPenrith Panth |
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| 08 Sep 18 | Playoff        | Penrith PanthersPenrith Panth | 27 - 12 | New Zealand WarriorsNew Zealand W |
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| 14 Sep 18 | QF        | Cronulla SharksCronulla Shar | 21 - 20 | Penrith PanthersPenrith Panth |