| 06 Mar 16 | r01        | Gold Coast TitansGold Coast Ti | 30 - 12 | Newcastle Knights Newcastle Kni |
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| 12 Mar 16 | r02        | South Sydney RabbitohsSouth Sydney | 48 - 6 | Newcastle Knights Newcastle Kni |
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| 19 Mar 16 | r03        | Newcastle Knights Newcastle Kni | 24 - 24 | Canberra RaidersCanberra Raid |
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| 28 Mar 16 | r04        | New Zealand WarriorsNew Zealand W | 40 - 18 | Newcastle Knights Newcastle Kni |
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| 02 Apr 16 | r05        | Melbourne StormMelbourne Sto | 18 - 14 | Newcastle Knights Newcastle Kni |
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| 10 Apr 16 | r06        | Newcastle Knights Newcastle Kni | 18 - 16 | Wests TigersWests Tigers |
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| 16 Apr 16 | r07        | Brisbane BroncosBrisbane Bron | 53 - 0 | Newcastle Knights Newcastle Kni |
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| 25 Apr 16 | r08        | Newcastle Knights Newcastle Kni | 10 - 26 | Manly Sea EaglesManly Sea Eag |
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| 30 Apr 16 | r09        | Sydney RoostersSydney Rooste | 38 - 0 | Newcastle Knights Newcastle Kni |
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| 15 May 16 | r10        | Newcastle Knights Newcastle Kni | 0 - 62 | Cronulla SharksCronulla Shar |
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| 21 May 16 | r11        | Wests TigersWests Tigers | 20 - 12 | Newcastle Knights Newcastle Kni |
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| 30 May 16 | r12        | Newcastle Knights Newcastle Kni | 18 - 20 | Parramatta EelsParramatta Ee |
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| 04 Jun 16 | r13        | North Queensland Cowboys North Queensl | 46 - 16 | Newcastle Knights Newcastle Kni |
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| 11 Jun 16 | r14        | Newcastle Knights Newcastle Kni | 14 - 50 | New Zealand WarriorsNew Zealand W |
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| 25 Jun 16 | r16        | Newcastle Knights Newcastle Kni | 18 - 30 | St. George Illawara DragoSt. George Il |
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| 03 Jul 16 | r17        | Canberra RaidersCanberra Raid | 29 - 25 | Newcastle Knights Newcastle Kni |
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| 17 Jul 16 | r19        | Newcastle Knights Newcastle Kni | 16 - 20 | Melbourne StormMelbourne Sto |
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| 24 Jul 16 | r20        | Cronulla SharksCronulla Shar | 36 - 4 | Newcastle Knights Newcastle Kni |
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| 31 Jul 16 | r21        | Manly Sea EaglesManly Sea Eag | 36 - 16 | Newcastle Knights Newcastle Kni |
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| 06 Aug 16 | r22        | Newcastle Knights Newcastle Kni | 14 - 28 | Canterbury Bankstown BullCanterbury Ba |
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| 14 Aug 16 | r23        | Newcastle Knights Newcastle Kni | 6 - 42 | Penrith PanthersPenrith Panth |
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| 20 Aug 16 | r24        | Newcastle Knights Newcastle Kni | 6 - 26 | Gold Coast TitansGold Coast Ti |
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| 28 Aug 16 | r25        | Newcastle Knights Newcastle Kni | 12 - 34 | South Sydney RabbitohsSouth Sydney |
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| 03 Sep 16 | r26        | St. George Illawara DragoSt. George Il | 28 - 26 | Newcastle Knights Newcastle Kni |