| 26 Dec 20 | r04        | HarlequinsHarlequins | 19 - 27 | Bristol RugbyBristol Rugby |
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| 01 Jan 21 | r05        | Bristol RugbyBristol Rugby | 29 - 17 | Newcastle FalconsNewcastle Fal |
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| 09 Jan 21 | r06        | Exeter ChiefsExeter Chiefs | 7 - 20 | Bristol RugbyBristol Rugby |
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| 30 Jan 21 | r07        | Bristol RugbyBristol Rugby | 48 - 3 | Bath RugbyBath Rugby |
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| 06 Feb 21 | r08        | Bristol RugbyBristol Rugby | 13 - 20 | Sale SharksSale Sharks |
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| 13 Feb 21 | r09        | GloucesterGloucester | 17 - 18 | Bristol RugbyBristol Rugby |
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| 20 Feb 21 | r10        | London IrishLondon Irish | 34 - 34 | Bristol RugbyBristol Rugby |
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| 27 Feb 21 | r11        | Bristol RugbyBristol Rugby | 17 - 3 | Leicester TigersLeicester Tig |
| |
| 06 Mar 21 | r12        | Worcester WarriorsWorcester War | 23 - 24 | Bristol RugbyBristol Rugby |
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| 13 Mar 21 | r13        | Bristol RugbyBristol Rugby | 37 - 20 | WaspsWasps |
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| 20 Mar 21 | r14        | Northampton SaintsNorthampton S | 21 - 28 | Bristol RugbyBristol Rugby |
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| 27 Mar 21 | r15        | Bristol RugbyBristol Rugby | 35 - 33 | HarlequinsHarlequins |
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| 17 Apr 21 | r16        | Newcastle FalconsNewcastle Fal | 17 - 34 | Bristol RugbyBristol Rugby |
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| 24 Apr 21 | r17        | Bristol RugbyBristol Rugby | 12 - 20 | Exeter ChiefsExeter Chiefs |
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| 08 May 21 | r18        | Bath RugbyBath Rugby | 20 - 40 | Bristol RugbyBristol Rugby |
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| 15 May 21 | r19        | Bristol RugbyBristol Rugby | - | GloucesterGloucester |
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| 29 May 21 | r20        | Sale SharksSale Sharks | 22 - 12 | Bristol RugbyBristol Rugby |
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| 05 Jun 21 | r21        | Leicester TigersLeicester Tig | 23 - 26 | Bristol RugbyBristol Rugby |
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| 12 Jun 21 | r22        | Bristol RugbyBristol Rugby | P - P | London IrishLondon Irish |
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| 19 Jun 21 | r00        | Bristol RugbyBristol Rugby | 36 - 43 | HarlequinsHarlequins |