| 26 Dec 20 | r04        | Exeter ChiefsExeter Chiefs | 28 - 20 | GloucesterGloucester |
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| 02 Jan 21 | r05        | WaspsWasps | 34 - 5 | Exeter ChiefsExeter Chiefs |
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| 09 Jan 21 | r06        | Exeter ChiefsExeter Chiefs | 7 - 20 | Bristol RugbyBristol Rugby |
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| 30 Jan 21 | r07        | Worcester WarriorsWorcester War | 17 - 21 | Exeter ChiefsExeter Chiefs |
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| 06 Feb 21 | r08        | Newcastle FalconsNewcastle Fal | 9 - 15 | Exeter ChiefsExeter Chiefs |
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| 13 Feb 21 | r09        | Exeter ChiefsExeter Chiefs | 26 - 3 | London IrishLondon Irish |
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| 20 Feb 21 | r10        | Exeter ChiefsExeter Chiefs | 12 - 13 | Northampton SaintsNorthampton S |
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| 26 Feb 21 | r11        | Sale SharksSale Sharks | 25 - 20 | Exeter ChiefsExeter Chiefs |
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| 06 Mar 21 | r12        | Bath RugbyBath Rugby | 16 - 38 | Exeter ChiefsExeter Chiefs |
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| 13 Mar 21 | r13        | Exeter ChiefsExeter Chiefs | 21 - 20 | HarlequinsHarlequins |
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| 20 Mar 21 | r14        | Exeter ChiefsExeter Chiefs | 37 - 31 | Leicester TigersLeicester Tig |
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| 27 Mar 21 | r15        | GloucesterGloucester | 34 - 18 | Exeter ChiefsExeter Chiefs |
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| 17 Apr 21 | r16        | Exeter ChiefsExeter Chiefs | 43 - 13 | WaspsWasps |
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| 24 Apr 21 | r17        | Bristol RugbyBristol Rugby | 12 - 20 | Exeter ChiefsExeter Chiefs |
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| 08 May 21 | r18        | Exeter ChiefsExeter Chiefs | 41 - 10 | Worcester WarriorsWorcester War |
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| 15 May 21 | r19        | London IrishLondon Irish | - | Exeter ChiefsExeter Chiefs |
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| 29 May 21 | r20        | Exeter ChiefsExeter Chiefs | 74 - 3 | Newcastle FalconsNewcastle Fal |
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| 05 Jun 21 | r21        | Northampton SaintsNorthampton S | 26 - 29 | Exeter ChiefsExeter Chiefs |
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| 12 Jun 21 | r22        | Exeter ChiefsExeter Chiefs | 20 - 19 | Sale SharksSale Sharks |
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| 19 Jun 21 | r00        | Exeter ChiefsExeter Chiefs | 40 - 30 | Sale SharksSale Sharks |
| 26 Jun 21 | r00        | Exeter ChiefsExeter Chiefs | 38 - 40 | HarlequinsHarlequins |