

Team 2021 Scheduals| 15 Feb |
r01 ![]() | Estudiantes de la PlataEstudiantes d | 2 - 1 | River PlateRiver Plate |
| 21 Feb |
r02 ![]() | River PlateRiver Plate | 3 - 0 | Rosario CentralRosario Centr |
| 28 Feb |
r03 ![]() | PlatensePlatense | 0 - 1 | River PlateRiver Plate |
| 09 Mar |
r04 ![]() | River PlateRiver Plate | 0 - 1 | Argentinos JuniorsArgentinos Ju |
| 14 Mar |
r05 ![]() | Boca JuniorsBoca Juniors | 1 - 1 | River PlateRiver Plate |
| 21 Mar |
r06 ![]() | Godoy CruzGodoy Cruz | 1 - 6 | River PlateRiver Plate |
| 28 Mar |
r07 | River PlateRiver Plate | 0 - 0 | Racing ClubRacing Club |
| 04 Apr |
r08 ![]() | Arsenal SarandiArsenal Saran | 0 - 0 | River PlateRiver Plate |
| 12 Apr |
r09 ![]() | River PlateRiver Plate | 3 - 2 | ColonColon |
| 17 Apr |
r10 ![]() | Central Córdoba de SantiCentral Córd | 0 - 5 | River PlateRiver Plate |
| 25 Apr |
r11 ![]() | River PlateRiver Plate | 1 - 2 | San LorenzoSan Lorenzo |
| 02 May |
r12 ![]() | BanfieldBanfield | 1 - 0 | River PlateRiver Plate |
| 09 May |
r13 ![]() | River PlateRiver Plate | 4 - 1 | AldosiviAldosivi |
| 16 May |
QF![]() | Boca JuniorsBoca Juniors | 1 - 1 | River PlateRiver Plate |
| 18 Jul |
r01 ![]() | River PlateRiver Plate | 1 - 2 | ColonColon |
| 25 Jul |
r02 ![]() | River PlateRiver Plate | 4 - 0 | UnionUnion |
| 29 Jul |
r03 ![]() | LanusLanus | 0 - 3 | River PlateRiver Plate |
| 01 Aug |
r04 | River PlateRiver Plate | 1 - 1 | HuracanHuracan |
| 07 Aug |
r05 | Godoy CruzGodoy Cruz | 2 - 1 | River PlateRiver Plate |
| 14 Aug |
r06 | River PlateRiver Plate | 2 - 0 | Velez SarsfieldVelez Sarsfie |
| 22 Aug |
r07 | Gimnasia LPGimnasia LP | 1 - 1 | River PlateRiver Plate |
| 27 Aug |
r08 | River PlateRiver Plate | 2 - 0 | AldosiviAldosivi |
| 30 Aug |
r09 | SarmientoSarmiento | 1 - 2 | River PlateRiver Plate |
| 06 Sep |
r10 | River PlateRiver Plate | 1 - 1 | IndependienteIndependiente |
| 16 Sep |
r11 | Newells Old BoysNewells Old B | 1 - 4 | River PlateRiver Plate |
| 19 Sep |
r12 | River PlateRiver Plate | 1 - 0 | Arsenal SarandiArsenal Saran |
| 25 Sep |
r13 | Central Córdoba de SantiCentral Córd | 1 - 3 | River PlateRiver Plate |
| 03 Oct |
r14 | River PlateRiver Plate | 2 - 1 | Boca JuniorsBoca Juniors |
| 09 Oct |
r15 | BanfieldBanfield | 0 - 1 | River PlateRiver Plate |
| 17 Oct |
r16 | River PlateRiver Plate | 3 - 1 | San LorenzoSan Lorenzo |
| 22 Oct |
r17 ![]() | Talleres de CordobaTalleres de C | 0 - 2 | River PlateRiver Plate |
| 25 Oct |
r18 ![]() | River PlateRiver Plate | 3 - 0 | Argentinos JuniorsArgentinos Ju |
| 31 Oct |
r19 | Estudiantes de la PlataEstudiantes d | 1 - 1 | River PlateRiver Plate |
| 07 Nov |
r20 | River PlateRiver Plate | 5 - 0 | Patronato de ParanaPatronato de |
| 22 Nov |
r21 ![]() | PlatensePlatense | 0 - 1 | River PlateRiver Plate |
| 26 Nov |
r22 | River PlateRiver Plate | 4 - 0 | Racing ClubRacing Club |
| 28 Nov |
r23 | Rosario CentralRosario Centr | 2 - 2 | River PlateRiver Plate |
| 06 Dec |
r24 | River PlateRiver Plate | 2 - 3 | Defensa y JusticiaDefensa y Jus |
| 11 Dec |
r25 | Atletico TucumanAtletico Tucu | 1 - 1 | River PlateRiver Plate |