| 15 Feb 21 | r01        | Estudiantes de la PlataEstudiantes d | 2 - 1 | River PlateRiver Plate |
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| 21 Feb 21 | r02        | River PlateRiver Plate | 3 - 0 | Rosario CentralRosario Centr |
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| 28 Feb 21 | r03        | PlatensePlatense | 0 - 1 | River PlateRiver Plate |
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| 09 Mar 21 | r04        | River PlateRiver Plate | 0 - 1 | Argentinos JuniorsArgentinos Ju |
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| 14 Mar 21 | r05        | Boca JuniorsBoca Juniors | 1 - 1 | River PlateRiver Plate |
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| 21 Mar 21 | r06        | Godoy CruzGodoy Cruz | 1 - 6 | River PlateRiver Plate |
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| 28 Mar 21 | r07        | River PlateRiver Plate | 0 - 0 | Racing ClubRacing Club |
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| 04 Apr 21 | r08        | Arsenal SarandiArsenal Saran | 0 - 0 | River PlateRiver Plate |
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| 12 Apr 21 | r09        | River PlateRiver Plate | 3 - 2 | ColonColon |
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| 17 Apr 21 | r10        | Central Córdoba de SantiaCentral Córdo | 0 - 5 | River PlateRiver Plate |
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| 25 Apr 21 | r11        | River PlateRiver Plate | 1 - 2 | San LorenzoSan Lorenzo |
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| 02 May 21 | r12        | BanfieldBanfield | 1 - 0 | River PlateRiver Plate |
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| 09 May 21 | r13        | River PlateRiver Plate | 4 - 1 | AldosiviAldosivi |
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| 16 May 21 | QF        | Boca JuniorsBoca Juniors | 1 - 1 | River PlateRiver Plate |
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| 18 Jul 21 | r01        | River PlateRiver Plate | 1 - 2 | ColonColon |
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| 25 Jul 21 | r02        | River PlateRiver Plate | 4 - 0 | UnionUnion |
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| 29 Jul 21 | r03        | LanusLanus | 0 - 3 | River PlateRiver Plate |
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| 01 Aug 21 | r04        | River PlateRiver Plate | 1 - 1 | HuracanHuracan |
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| 08 Aug 21 | r05        | Godoy CruzGodoy Cruz | 2 - 1 | River PlateRiver Plate |
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| 14 Aug 21 | r06        | River PlateRiver Plate | 2 - 0 | Velez SarsfieldVelez Sarsfie |
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| 23 Aug 21 | r07        | Gimnasia LPGimnasia LP | 1 - 1 | River PlateRiver Plate |
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| 27 Aug 21 | r08        | River PlateRiver Plate | 2 - 0 | AldosiviAldosivi |
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| 30 Aug 21 | r09        | SarmientoSarmiento | 1 - 2 | River PlateRiver Plate |
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| 06 Sep 21 | r10        | River PlateRiver Plate | 1 - 1 | IndependienteIndependiente |
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| 16 Sep 21 | r11        | Newells Old BoysNewells Old B | 1 - 4 | River PlateRiver Plate |
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| 20 Sep 21 | r12        | River PlateRiver Plate | 1 - 0 | Arsenal SarandiArsenal Saran |
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| 26 Sep 21 | r13        | Central Córdoba de SantiaCentral Córdo | 1 - 3 | River PlateRiver Plate |
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| 03 Oct 21 | r14        | River PlateRiver Plate | 2 - 1 | Boca JuniorsBoca Juniors |
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| 09 Oct 21 | r15        | BanfieldBanfield | 0 - 1 | River PlateRiver Plate |
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| 18 Oct 21 | r16        | River PlateRiver Plate | 3 - 1 | San LorenzoSan Lorenzo |
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| 22 Oct 21 | r17        | Talleres de CordobaTalleres de C | 0 - 2 | River PlateRiver Plate |
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| 25 Oct 21 | r18        | River PlateRiver Plate | 3 - 0 | Argentinos JuniorsArgentinos Ju |
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| 31 Oct 21 | r19        | Estudiantes de la PlataEstudiantes d | 1 - 1 | River PlateRiver Plate |
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| 07 Nov 21 | r20        | River PlateRiver Plate | 5 - 0 | Patronato de ParanaPatronato de |
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| 22 Nov 21 | r21        | PlatensePlatense | 0 - 1 | River PlateRiver Plate |
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| 26 Nov 21 | r22        | River PlateRiver Plate | 4 - 0 | Racing ClubRacing Club |
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| 28 Nov 21 | r23        | Rosario CentralRosario Centr | 2 - 2 | River PlateRiver Plate |
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| 06 Dec 21 | r24        | River PlateRiver Plate | 2 - 3 | Defensa y JusticiaDefensa y Jus |
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| 11 Dec 21 | r25        | Atletico TucumanAtletico Tucu | 1 - 1 | River PlateRiver Plate |