| 13 Jun 10 | r00  | Saskatchewan RoughridersSaskatchewan | 17 - 19 | BC LionsBC Lions |
| 20 Jun 10 | r00 | Calgary StampedersCalgary Stamp | 41 - 17 | Saskatchewan RoughridersSaskatchewan |
| 01 Jul 10 | r00 | Saskatchewan RoughridersSaskatchewan | 54 - 51 | Montreal AlouettesMontreal Alou |
| 11 Jul 10 | r00 | BC LionsBC Lions | 18 - 37 | Saskatchewan RoughridersSaskatchewan |
| 17 Jul 10 | r00 | Saskatchewan RoughridersSaskatchewan | 24 - 20 | Edmonton EskimosEdmonton Eski |
| 25 Jul 10 | r00 | Calgary StampedersCalgary Stamp | 40 - 20 | Saskatchewan RoughridersSaskatchewan |
| 31 Jul 10 | r00 | Saskatchewan RoughridersSaskatchewan | 37 - 24 | Hamilton Tiger-CatsHamilton Tige |
| 06 Aug 10 | r00 | Montreal AlouettesMontreal Alou | 30 - 26 | Saskatchewan RoughridersSaskatchewan |
| 13 Aug 10 | r00 | Saskatchewan RoughridersSaskatchewan | 37 - 13 | BC LionsBC Lions |
| 28 Aug 10 | r00 | Edmonton EskimosEdmonton Eski | 17 - 14 | Saskatchewan RoughridersSaskatchewan |
| 05 Sep 10 | r00 | Saskatchewan RoughridersSaskatchewan | 27 - 23 | Winnipeg Blue BombersWinnipeg Blue |
| 12 Sep 10 | r00 | Winnipeg Blue BombersWinnipeg Blue | 31 - 2 | Saskatchewan RoughridersSaskatchewan |
| 18 Sep 10 | r00 | Saskatchewan RoughridersSaskatchewan | 43 - 37 | Calgary StampedersCalgary Stamp |
| 25 Sep 10 | r00 | Hamilton Tiger-CatsHamilton Tige | 25 - 32 | Saskatchewan RoughridersSaskatchewan |
| 02 Oct 10 | r00 | Toronto ArgonautsToronto Argon | 16 - 27 | Saskatchewan RoughridersSaskatchewan |
| 09 Oct 10 | r00 | Saskatchewan RoughridersSaskatchewan | 19 - 24 | Toronto ArgonautsToronto Argon |
| 17 Oct 10 | r00 | Saskatchewan RoughridersSaskatchewan | 26 - 34 | Calgary StampedersCalgary Stamp |
| 23 Oct 10 | r00 | Edmonton EskimosEdmonton Eski | 39 - 24 | Saskatchewan RoughridersSaskatchewan |
| 31 Oct 10 | r00 | BC LionsBC Lions | 23 - 17 | Saskatchewan RoughridersSaskatchewan |
| 06 Nov 10 | r00 | Saskatchewan RoughridersSaskatchewan | 31 - 23 | Edmonton EskimosEdmonton Eski |
| 14 Nov 10 | r00 | Saskatchewan RoughridersSaskatchewan | 41 - 38 | BC LionsBC Lions |
| 21 Nov 10 | r00 | Calgary StampedersCalgary Stamp | 16 - 20 | Saskatchewan RoughridersSaskatchewan |
| 28 Nov 10 | r00  | Saskatchewan RoughridersSaskatchewan | 18 - 21 | Montreal AlouettesMontreal Alou |
Team 2010 Schedules
BC Lions
Calgary Stampeders
Edmonton Elks
Hamilton Tiger-Cats
Montreal Alouettes
Ottawa Redblacks
Saskatchewan Roughriders
Toronto Argonauts
Winnipeg Blue Bombers
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