| 13 Jun 10 | r00        | Edmonton EskimosEdmonton Eski | 21 - 23 | Calgary StampedersCalgary Stamp |
| 20 Jun 10 | r00        | BC LionsBC Lions | 32 - 36 | Edmonton EskimosEdmonton Eski |
| 04 Jul 10 | r00        | Edmonton EskimosEdmonton Eski | 10 - 25 | BC LionsBC Lions |
| 11 Jul 10 | r00        | Edmonton EskimosEdmonton Eski | 23 - 33 | Montreal AlouettesMontreal Alou |
| 17 Jul 10 | r00        | Saskatchewan RoughridersSaskatchewan | 24 - 20 | Edmonton EskimosEdmonton Eski |
| 24 Jul 10 | r00        | Winnipeg Blue BombersWinnipeg Blue | 47 - 21 | Edmonton EskimosEdmonton Eski |
| 31 Jul 10 | r00        | Edmonton EskimosEdmonton Eski | 28 - 25 | BC LionsBC Lions |
| 07 Aug 10 | r00        | Edmonton EskimosEdmonton Eski | 28 - 29 | Toronto ArgonautsToronto Argon |
| 16 Aug 10 | r00        | Calgary StampedersCalgary Stamp | 56 - 15 | Edmonton EskimosEdmonton Eski |
| 28 Aug 10 | r00        | Edmonton EskimosEdmonton Eski | 17 - 14 | Saskatchewan RoughridersSaskatchewan |
| 06 Sep 10 | r00        | Calgary StampedersCalgary Stamp | 52 - 5 | Edmonton EskimosEdmonton Eski |
| 11 Sep 10 | r00        | Edmonton EskimosEdmonton Eski | 20 - 36 | Calgary StampedersCalgary Stamp |
| 19 Sep 10 | r00        | Montreal AlouettesMontreal Alou | 31 - 14 | Edmonton EskimosEdmonton Eski |
| 26 Sep 10 | r00        | Toronto ArgonautsToronto Argon | 6 - 24 | Edmonton EskimosEdmonton Eski |
| 03 Oct 10 | r00        | Edmonton EskimosEdmonton Eski | 37 - 35 | Hamilton Tiger-CatsHamilton Tige |
| 08 Oct 10 | r00        | Hamilton Tiger-CatsHamilton Tige | 36 - 11 | Edmonton EskimosEdmonton Eski |
| 17 Oct 10 | r00        | BC LionsBC Lions | 28 - 31 | Edmonton EskimosEdmonton Eski |
| 23 Oct 10 | r00        | Edmonton EskimosEdmonton Eski | 39 - 24 | Saskatchewan RoughridersSaskatchewan |
| 30 Oct 10 | r00        | Edmonton EskimosEdmonton Eski | 16 - 13 | Winnipeg Blue BombersWinnipeg Blue |
| 06 Nov 10 | r00        | Saskatchewan RoughridersSaskatchewan | 31 - 23 | Edmonton EskimosEdmonton Eski |