| 17 Jul 22 | r01        | PaderbornPaderborn | 5 - 0 | KarlsruheKarlsruhe |
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| 24 Jul 22 | r02        | KarlsruheKarlsruhe | 2 - 3 | MagdeburgMagdeburg |
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| 05 Aug 22 | r03        | SPVGG Greuther FürthSPVGG Greuthe | 1 - 1 | KarlsruheKarlsruhe |
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| 13 Aug 22 | r04        | KarlsruheKarlsruhe | 3 - 2 | SandhausenSandhausen |
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| 20 Aug 22 | r05        | Jahn RegensburgJahn Regensbu | 0 - 6 | KarlsruheKarlsruhe |
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| 27 Aug 22 | r06        | KarlsruheKarlsruhe | 2 - 0 | Hansa RostockHansa Rostock |
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| 03 Sep 22 | r07        | HamburgHamburg | 1 - 0 | KarlsruheKarlsruhe |
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| 10 Sep 22 | r08        | KarlsruheKarlsruhe | 0 - 0 | FC HeidenheimFC Heidenheim |
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| 16 Sep 22 | r09        | BraunschweigBraunschweig | 2 - 1 | KarlsruheKarlsruhe |
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| 02 Oct 22 | r10        | KarlsruheKarlsruhe | 3 - 0 | NurnbergNurnberg |
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| 07 Oct 22 | r11        | BielefeldBielefeld | 1 - 2 | KarlsruheKarlsruhe |
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| 15 Oct 22 | r12        | KarlsruheKarlsruhe | 1 - 2 | DarmstadtDarmstadt |
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| 23 Oct 22 | r13        | KarlsruheKarlsruhe | 0 - 2 | Fortuna DüsseldorfFortuna Düsse |
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| 30 Oct 22 | r14        | HannoverHannover | 1 - 0 | KarlsruheKarlsruhe |
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| 05 Nov 22 | r15        | KarlsruheKarlsruhe | 1 - 4 | Holstein KielHolstein Kiel |
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| 08 Nov 22 | r16        | KaiserslauternKaiserslauter | 2 - 0 | KarlsruheKarlsruhe |
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| 12 Nov 22 | r17        | KarlsruheKarlsruhe | 4 - 4 | St PauliSt Pauli |
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| 27 Jan 23 | r18        | KarlsruheKarlsruhe | 0 - 1 | PaderbornPaderborn |
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| 05 Feb 23 | r19        | MagdeburgMagdeburg | 1 - 1 | KarlsruheKarlsruhe |
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| 10 Feb 23 | r20        | KarlsruheKarlsruhe | 2 - 1 | SPVGG Greuther FürthSPVGG Greuthe |
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| 19 Feb 23 | r21        | SandhausenSandhausen | 0 - 3 | KarlsruheKarlsruhe |
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| 24 Feb 23 | r22        | KarlsruheKarlsruhe | 1 - 0 | Jahn RegensburgJahn Regensbu |
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| 05 Mar 23 | r23        | Hansa RostockHansa Rostock | 0 - 2 | KarlsruheKarlsruhe |
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| 12 Mar 23 | r24        | KarlsruheKarlsruhe | 4 - 2 | HamburgHamburg |
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| 17 Mar 23 | r25        | FC HeidenheimFC Heidenheim | 5 - 2 | KarlsruheKarlsruhe |
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| 01 Apr 23 | r26        | KarlsruheKarlsruhe | 1 - 1 | BraunschweigBraunschweig |
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| 08 Apr 23 | r27        | NurnbergNurnberg | 1 - 1 | KarlsruheKarlsruhe |
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| 16 Apr 23 | r28        | KarlsruheKarlsruhe | 4 - 2 | BielefeldBielefeld |
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| 21 Apr 23 | r29        | DarmstadtDarmstadt | 2 - 1 | KarlsruheKarlsruhe |
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| 30 Apr 23 | r30        | Fortuna DüsseldorfFortuna Düsse | 3 - 2 | KarlsruheKarlsruhe |
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| 06 May 23 | r31        | KarlsruheKarlsruhe | 2 - 1 | HannoverHannover |
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| 13 May 23 | r32        | Holstein KielHolstein Kiel | 2 - 1 | KarlsruheKarlsruhe |
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| 21 May 23 | r33        | KarlsruheKarlsruhe | 2 - 0 | KaiserslauternKaiserslauter |
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| 28 May 23 | r34        | St PauliSt Pauli | 1 - 1 | KarlsruheKarlsruhe |