| 19 Sep 20 | r01        | HannoverHannover | 2 - 0 | KarlsruheKarlsruhe |
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| 27 Sep 20 | r02        | KarlsruheKarlsruhe | 0 - 1 | BochumBochum |
| |
| 03 Oct 20 | r03        | Jahn RegensburgJahn Regensbu | 1 - 0 | KarlsruheKarlsruhe |
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| 17 Oct 20 | r04        | KarlsruheKarlsruhe | 3 - 0 | SandhausenSandhausen |
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| 23 Oct 20 | r05        | NurnbergNurnberg | 1 - 1 | KarlsruheKarlsruhe |
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| 01 Nov 20 | r06        | KarlsruheKarlsruhe | 3 - 4 | DarmstadtDarmstadt |
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| 08 Nov 20 | r07        | St PauliSt Pauli | 0 - 3 | KarlsruheKarlsruhe |
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| 21 Nov 20 | r08        | BraunschweigBraunschweig | 1 - 3 | KarlsruheKarlsruhe |
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| 28 Nov 20 | r09        | KarlsruheKarlsruhe | 1 - 0 | PaderbornPaderborn |
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| 05 Dec 20 | r10        | OsnabrueckOsnabrueck | 1 - 2 | KarlsruheKarlsruhe |
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| 13 Dec 20 | r11        | KarlsruheKarlsruhe | 1 - 2 | Fortuna DüsseldorfFortuna Düsse |
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| 17 Dec 20 | r12        | AueAue | 4 - 1 | KarlsruheKarlsruhe |
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| 21 Dec 20 | r13        | KarlsruheKarlsruhe | 1 - 2 | HamburgHamburg |
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| 02 Jan 21 | r14        | Wuerzburger KickersWuerzburger K | 2 - 4 | KarlsruheKarlsruhe |
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| 08 Jan 21 | r15        | KarlsruheKarlsruhe | 3 - 2 | SPVGG Greuther FürthSPVGG Greuthe |
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| 17 Jan 21 | r16        | Holstein KielHolstein Kiel | 2 - 3 | KarlsruheKarlsruhe |
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| 23 Jan 21 | r17        | KarlsruheKarlsruhe | 1 - 1 | FC HeidenheimFC Heidenheim |
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| 27 Jan 21 | r18        | KarlsruheKarlsruhe | 1 - 0 | HannoverHannover |
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| 31 Jan 21 | r19        | BochumBochum | 1 - 2 | KarlsruheKarlsruhe |
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| 07 Feb 21 | r20        | KarlsruheKarlsruhe | 0 - 0 | Jahn RegensburgJahn Regensbu |
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| 13 Feb 21 | r21        | SandhausenSandhausen | 2 - 3 | KarlsruheKarlsruhe |
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| 21 Feb 21 | r22        | KarlsruheKarlsruhe | 0 - 1 | NurnbergNurnberg |
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| 26 Feb 21 | r23        | DarmstadtDarmstadt | 0 - 1 | KarlsruheKarlsruhe |
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| 06 Mar 21 | r24        | KarlsruheKarlsruhe | 0 - 0 | St PauliSt Pauli |
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| 14 Mar 21 | r25        | KarlsruheKarlsruhe | 0 - 0 | BraunschweigBraunschweig |
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| 19 Mar 21 | r26        | PaderbornPaderborn | 2 - 2 | KarlsruheKarlsruhe |
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| 03 Apr 21 | r27        | KarlsruheKarlsruhe | 0 - 1 | OsnabrueckOsnabrueck |
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| 23 Apr 21 | r31        | KarlsruheKarlsruhe | 2 - 2 | Wuerzburger KickersWuerzburger K |
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| 26 Apr 21 | r29        | KarlsruheKarlsruhe | 0 - 0 | AueAue |
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| 29 Apr 21 | r30        | HamburgHamburg | 1 - 1 | KarlsruheKarlsruhe |
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| 03 May 21 | r28        | Fortuna DüsseldorfFortuna Düsse | 3 - 2 | KarlsruheKarlsruhe |
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| 08 May 21 | r32        | SPVGG Greuther FürthSPVGG Greuthe | 2 - 2 | KarlsruheKarlsruhe |
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| 16 May 21 | r33        | KarlsruheKarlsruhe | 3 - 2 | Holstein KielHolstein Kiel |
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| 23 May 21 | r34        | FC HeidenheimFC Heidenheim | 1 - 2 | KarlsruheKarlsruhe |