| 30 Jul 22 | r01        | PlymouthPlymouth | 1 - 0 | BarnsleyBarnsley |
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| 06 Aug 22 | r02        | Fleetwood TownFleetwood Tow | 2 - 1 | PlymouthPlymouth |
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| 13 Aug 22 | r03        | PlymouthPlymouth | 2 - 0 | PeterboroPeterboro |
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| 16 Aug 22 | r04        | CharltonCharlton | 5 - 1 | PlymouthPlymouth |
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| 20 Aug 22 | r05        | Forest Green RoversForest Green | 0 - 3 | PlymouthPlymouth |
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| 27 Aug 22 | r06        | PlymouthPlymouth | 2 - 0 | BoltonBolton |
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| 03 Sep 22 | r07        | DerbyDerby | 2 - 3 | PlymouthPlymouth |
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| 13 Sep 22 | r09        | PlymouthPlymouth | 1 - 0 | Oxford UtdOxford Utd |
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| 17 Sep 22 | r10        | PortsmouthPortsmouth | 2 - 2 | PlymouthPlymouth |
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| 25 Sep 22 | r11        | PlymouthPlymouth | 2 - 1 | IpswichIpswich |
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| 01 Oct 22 | r12        | WycombeWycombe | 0 - 1 | PlymouthPlymouth |
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| 04 Oct 22 | r08        | PlymouthPlymouth | 2 - 1 | Sheffield WedsSheffield Wed |
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| 08 Oct 22 | r14        | PlymouthPlymouth | 3 - 0 | AccringtonAccrington |
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| 15 Oct 22 | r15        | Milton Keynes DonsMilton Keynes | 1 - 4 | PlymouthPlymouth |
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| 22 Oct 22 | r16        | Bristol RoversBristol Rover | 2 - 2 | PlymouthPlymouth |
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| 25 Oct 22 | r13        | PlymouthPlymouth | 2 - 1 | ShrewsburyShrewsbury |
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| 31 Oct 22 | r17        | PlymouthPlymouth | 4 - 2 | ExeterExeter |
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| 12 Nov 22 | r18        | LincolnLincoln | 1 - 1 | PlymouthPlymouth |
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| 19 Nov 22 | r19        | BurtonBurton | 2 - 2 | PlymouthPlymouth |
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| 02 Dec 22 | r20        | PlymouthPlymouth | 0 - 2 | Port ValePort Vale |
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| 10 Dec 22 | r21        | Cambridge UnitedCambridge Uni | 0 - 0 | PlymouthPlymouth |
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| 17 Dec 22 | r22        | PlymouthPlymouth | 2 - 1 | MorecambeMorecambe |
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| 26 Dec 22 | r23        | CheltenhamCheltenham | 0 - 1 | PlymouthPlymouth |
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| 29 Dec 22 | r24        | PlymouthPlymouth | 1 - 0 | WycombeWycombe |
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| 01 Jan 23 | r25        | PlymouthPlymouth | 3 - 1 | Milton Keynes DonsMilton Keynes |
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| 07 Jan 23 | r38        | BoltonBolton | 0 - 0 | PlymouthPlymouth |
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| 14 Jan 23 | r27        | IpswichIpswich | 1 - 1 | PlymouthPlymouth |
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| 21 Jan 23 | r28        | PlymouthPlymouth | 4 - 2 | CheltenhamCheltenham |
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| 04 Feb 23 | r30        | Sheffield WedsSheffield Wed | 1 - 0 | PlymouthPlymouth |
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| 11 Feb 23 | r31        | PlymouthPlymouth | 3 - 1 | PortsmouthPortsmouth |
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| 14 Feb 23 | r32        | Oxford UtdOxford Utd | 1 - 3 | PlymouthPlymouth |
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| 18 Feb 23 | r33        | PlymouthPlymouth | 0 - 0 | Fleetwood TownFleetwood Tow |
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| 25 Feb 23 | r34        | PeterboroPeterboro | 5 - 2 | PlymouthPlymouth |
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| 04 Mar 23 | r35        | PlymouthPlymouth | 2 - 0 | CharltonCharlton |
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| 07 Mar 23 | r29        | PlymouthPlymouth | 2 - 1 | DerbyDerby |
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| 11 Mar 23 | r36        | BarnsleyBarnsley | 3 - 0 | PlymouthPlymouth |
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| 18 Mar 23 | r37        | PlymouthPlymouth | 2 - 0 | Forest Green RoversForest Green |
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| 21 Mar 23 | r26        | AccringtonAccrington | 0 - 2 | PlymouthPlymouth |
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| 07 Apr 23 | r40        | MorecambeMorecambe | 1 - 3 | PlymouthPlymouth |
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| 10 Apr 23 | r41        | PlymouthPlymouth | 0 - 2 | LincolnLincoln |
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| 15 Apr 23 | r42        | ExeterExeter | 0 - 1 | PlymouthPlymouth |
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| 18 Apr 23 | r43        | ShrewsburyShrewsbury | 1 - 2 | PlymouthPlymouth |
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| 22 Apr 23 | r44        | PlymouthPlymouth | 3 - 1 | Cambridge UnitedCambridge Uni |
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| 25 Apr 23 | r39        | PlymouthPlymouth | 2 - 0 | Bristol RoversBristol Rover |
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| 29 Apr 23 | r45        | PlymouthPlymouth | 1 - 0 | BurtonBurton |
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| 07 May 23 | r46        | Port ValePort Vale | 1 - 3 | PlymouthPlymouth |