| 13 Aug 22 | Pre        | Buffalo BillsBuffalo Bills | 27 - 24 | Indianapolis ColtsIndianapolis |
| 20 Aug 22 | Pre        | Buffalo BillsBuffalo Bills | 42 - 15 | Denver BroncosDenver Bronco |
| 26 Aug 22 | Pre        | Carolina PanthersCarolina Pant | 21 - 0 | Buffalo BillsBuffalo Bills |
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| 09 Sep 22 | r01        | Los Angeles RamsLos Angeles R | 10 - 31 | Buffalo BillsBuffalo Bills |
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| 19 Sep 22 | r02        | Buffalo BillsBuffalo Bills | 41 - 7 | Tennessee TitansTennessee Tit |
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| 25 Sep 22 | r03        | Miami DolphinsMiami Dolphin | 21 - 19 | Buffalo BillsBuffalo Bills |
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| 02 Oct 22 | r04        | Baltimore RavensBaltimore Rav | 20 - 23 | Buffalo BillsBuffalo Bills |
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| 09 Oct 22 | r05        | Buffalo BillsBuffalo Bills | 38 - 3 | Pittsburgh SteelersPittsburgh St |
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| 16 Oct 22 | r06        | Kansas City ChiefsKansas City C | 20 - 24 | Buffalo BillsBuffalo Bills |
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| 31 Oct 22 | r08        | Buffalo BillsBuffalo Bills | 27 - 17 | Green Bay PackersGreen Bay Pac |
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| 06 Nov 22 | r09        | New York JetsNew York Jets | 20 - 17 | Buffalo BillsBuffalo Bills |
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| 13 Nov 22 | r10        | Buffalo BillsBuffalo Bills | 30 - 33 | Minnesota VikingsMinnesota Vik |
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| 20 Nov 22 | r11        | Buffalo BillsBuffalo Bills | 31 - 23 | Cleveland BrownsCleveland Bro |
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| 24 Nov 22 | r12        | Detroit LionsDetroit Lions | 25 - 28 | Buffalo BillsBuffalo Bills |
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| 02 Dec 22 | r13        | New England PatriotsNew England P | 10 - 24 | Buffalo BillsBuffalo Bills |
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| 11 Dec 22 | r14        | Buffalo BillsBuffalo Bills | 20 - 12 | New York JetsNew York Jets |
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| 18 Dec 22 | r15        | Buffalo BillsBuffalo Bills | 32 - 29 | Miami DolphinsMiami Dolphin |
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| 24 Dec 22 | r16        | Chicago BearsChicago Bears | 13 - 35 | Buffalo BillsBuffalo Bills |
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| 03 Jan 23 | r17        | Cincinnati BengalsCincinnati Be | 7 - 3 | Buffalo BillsBuffalo Bills |
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| 08 Jan 23 | r18        | Buffalo BillsBuffalo Bills | 35 - 23 | New England PatriotsNew England P |
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| 15 Jan 23 | Playoff        | Buffalo BillsBuffalo Bills | 34 - 31 | Miami DolphinsMiami Dolphin |
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| 22 Jan 23 | QF        | Buffalo BillsBuffalo Bills | 10 - 27 | Cincinnati BengalsCincinnati Be |