| 12 Sep 21 | r01        | Tennessee TitansTennessee Tit | 13 - 38 | Arizona CardinalsArizona Cardi |
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| 19 Sep 21 | r02        | Arizona CardinalsArizona Cardi | 34 - 33 | Minnesota VikingsMinnesota Vik |
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| 26 Sep 21 | r03        | Jacksonville JaguarsJacksonville | 19 - 31 | Arizona CardinalsArizona Cardi |
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| 03 Oct 21 | r04        | Los Angeles RamsLos Angeles R | 20 - 37 | Arizona CardinalsArizona Cardi |
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| 10 Oct 21 | r05        | Arizona CardinalsArizona Cardi | 17 - 10 | San Francisco 49ersSan Francisco |
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| 17 Oct 21 | r06        | Cleveland BrownsCleveland Bro | 14 - 37 | Arizona CardinalsArizona Cardi |
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| 24 Oct 21 | r07        | Arizona CardinalsArizona Cardi | 31 - 5 | Houston TexansHouston Texan |
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| 29 Oct 21 | r08        | Arizona CardinalsArizona Cardi | 21 - 24 | Green Bay PackersGreen Bay Pac |
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| 07 Nov 21 | r09        | San Francisco 49ersSan Francisco | 17 - 31 | Arizona CardinalsArizona Cardi |
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| 14 Nov 21 | r10        | Arizona CardinalsArizona Cardi | 10 - 34 | Carolina PanthersCarolina Pant |
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| 21 Nov 21 | r11        | Seattle SeahawksSeattle Seaha | 13 - 23 | Arizona CardinalsArizona Cardi |
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| 05 Dec 21 | r13        | Chicago BearsChicago Bears | 22 - 33 | Arizona CardinalsArizona Cardi |
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| 14 Dec 21 | r14        | Arizona CardinalsArizona Cardi | 23 - 30 | Los Angeles RamsLos Angeles R |
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| 19 Dec 21 | r15        | Detroit LionsDetroit Lions | 30 - 12 | Arizona CardinalsArizona Cardi |
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| 26 Dec 21 | r16        | Arizona CardinalsArizona Cardi | 16 - 22 | Indianapolis ColtsIndianapolis |
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| 02 Jan 22 | r17        | Dallas CowboysDallas Cowboy | 22 - 25 | Arizona CardinalsArizona Cardi |
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| 09 Jan 22 | r18        | Arizona CardinalsArizona Cardi | 30 - 38 | Seattle SeahawksSeattle Seaha |
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| 18 Jan 22 | Playoff        | Los Angeles RamsLos Angeles R | 34 - 11 | Arizona CardinalsArizona Cardi |