| 12 Sep 21 | r01        | Carolina PanthersCarolina Pant | 19 - 14 | New York JetsNew York Jets |
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| 19 Sep 21 | r02        | Carolina PanthersCarolina Pant | 26 - 7 | New Orleans SaintsNew Orleans S |
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| 24 Sep 21 | r03        | Houston TexansHouston Texan | 9 - 24 | Carolina PanthersCarolina Pant |
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| 03 Oct 21 | r04        | Dallas CowboysDallas Cowboy | 36 - 28 | Carolina PanthersCarolina Pant |
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| 10 Oct 21 | r05        | Carolina PanthersCarolina Pant | 18 - 21 | Philadelphia EaglesPhiladelphia |
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| 17 Oct 21 | r06        | Carolina PanthersCarolina Pant | 28 - 34 | Minnesota VikingsMinnesota Vik |
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| 24 Oct 21 | r07        | New York GiantsNew York Gian | 25 - 3 | Carolina PanthersCarolina Pant |
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| 31 Oct 21 | r08        | Atlanta FalconsAtlanta Falco | 13 - 19 | Carolina PanthersCarolina Pant |
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| 07 Nov 21 | r09        | Carolina PanthersCarolina Pant | 6 - 24 | New England PatriotsNew England P |
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| 14 Nov 21 | r10        | Arizona CardinalsArizona Cardi | 10 - 34 | Carolina PanthersCarolina Pant |
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| 21 Nov 21 | r11        | Carolina PanthersCarolina Pant | 21 - 27 | WashingtonWashington |
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| 28 Nov 21 | r12        | Miami DolphinsMiami Dolphin | 33 - 10 | Carolina PanthersCarolina Pant |
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| 12 Dec 21 | r14        | Carolina PanthersCarolina Pant | 21 - 29 | Atlanta FalconsAtlanta Falco |
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| 19 Dec 21 | r15        | Buffalo BillsBuffalo Bills | 31 - 14 | Carolina PanthersCarolina Pant |
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| 26 Dec 21 | r16        | Carolina PanthersCarolina Pant | 6 - 32 | Tampa Bay BuccaneersTampa Bay Buc |
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| 02 Jan 22 | r17        | New Orleans SaintsNew Orleans S | 18 - 10 | Carolina PanthersCarolina Pant |
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| 09 Jan 22 | r18        | Tampa Bay BuccaneersTampa Bay Buc | 41 - 17 | Carolina PanthersCarolina Pant |