| 12 Sep 21 | r01        | Detroit LionsDetroit Lions | 33 - 41 | San Francisco 49ersSan Francisco |
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| 21 Sep 21 | r02        | Green Bay PackersGreen Bay Pac | 35 - 17 | Detroit LionsDetroit Lions |
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| 26 Sep 21 | r03        | Detroit LionsDetroit Lions | 17 - 19 | Baltimore RavensBaltimore Rav |
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| 03 Oct 21 | r04        | Chicago BearsChicago Bears | 24 - 14 | Detroit LionsDetroit Lions |
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| 10 Oct 21 | r05        | Minnesota VikingsMinnesota Vik | 19 - 17 | Detroit LionsDetroit Lions |
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| 17 Oct 21 | r06        | Detroit LionsDetroit Lions | 11 - 34 | Cincinnati BengalsCincinnati Be |
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| 24 Oct 21 | r07        | Los Angeles RamsLos Angeles R | 28 - 19 | Detroit LionsDetroit Lions |
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| 31 Oct 21 | r08        | Detroit LionsDetroit Lions | 6 - 44 | Philadelphia EaglesPhiladelphia |
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| 14 Nov 21 | r10        | Pittsburgh SteelersPittsburgh St | 16 - 16 | Detroit LionsDetroit Lions |
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| 21 Nov 21 | r11        | Cleveland BrownsCleveland Bro | 13 - 10 | Detroit LionsDetroit Lions |
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| 25 Nov 21 | r12        | Detroit LionsDetroit Lions | 14 - 16 | Chicago BearsChicago Bears |
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| 05 Dec 21 | r13        | Detroit LionsDetroit Lions | 29 - 27 | Minnesota VikingsMinnesota Vik |
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| 12 Dec 21 | r14        | Denver BroncosDenver Bronco | 38 - 10 | Detroit LionsDetroit Lions |
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| 19 Dec 21 | r15        | Detroit LionsDetroit Lions | 30 - 12 | Arizona CardinalsArizona Cardi |
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| 26 Dec 21 | r16        | Atlanta FalconsAtlanta Falco | 20 - 16 | Detroit LionsDetroit Lions |
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| 02 Jan 22 | r17        | Seattle SeahawksSeattle Seaha | 51 - 29 | Detroit LionsDetroit Lions |
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| 09 Jan 22 | r18        | Detroit LionsDetroit Lions | 37 - 30 | Green Bay PackersGreen Bay Pac |