| 13 Sep 21 | r01        | Los Angeles RamsLos Angeles R | 34 - 14 | Chicago BearsChicago Bears |
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| 19 Sep 21 | r02        | Chicago BearsChicago Bears | 20 - 17 | Cincinnati BengalsCincinnati Be |
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| 26 Sep 21 | r03        | Cleveland BrownsCleveland Bro | 26 - 6 | Chicago BearsChicago Bears |
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| 03 Oct 21 | r04        | Chicago BearsChicago Bears | 24 - 14 | Detroit LionsDetroit Lions |
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| 10 Oct 21 | r05        | Las Vegas RaidersLas Vegas Rai | 9 - 20 | Chicago BearsChicago Bears |
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| 17 Oct 21 | r06        | Chicago BearsChicago Bears | 14 - 24 | Green Bay PackersGreen Bay Pac |
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| 24 Oct 21 | r07        | Tampa Bay BuccaneersTampa Bay Buc | 38 - 3 | Chicago BearsChicago Bears |
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| 31 Oct 21 | r08        | Chicago BearsChicago Bears | 22 - 33 | San Francisco 49ersSan Francisco |
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| 09 Nov 21 | r09        | Pittsburgh SteelersPittsburgh St | 29 - 27 | Chicago BearsChicago Bears |
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| 21 Nov 21 | r11        | Chicago BearsChicago Bears | 13 - 16 | Baltimore RavensBaltimore Rav |
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| 25 Nov 21 | r12        | Detroit LionsDetroit Lions | 14 - 16 | Chicago BearsChicago Bears |
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| 05 Dec 21 | r13        | Chicago BearsChicago Bears | 22 - 33 | Arizona CardinalsArizona Cardi |
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| 13 Dec 21 | r14        | Green Bay PackersGreen Bay Pac | 45 - 30 | Chicago BearsChicago Bears |
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| 21 Dec 21 | r15        | Chicago BearsChicago Bears | 9 - 17 | Minnesota VikingsMinnesota Vik |
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| 26 Dec 21 | r16        | Seattle SeahawksSeattle Seaha | 24 - 25 | Chicago BearsChicago Bears |
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| 02 Jan 22 | r17        | Chicago BearsChicago Bears | 29 - 3 | New York GiantsNew York Gian |
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| 09 Jan 22 | r18        | Minnesota VikingsMinnesota Vik | 31 - 17 | Chicago BearsChicago Bears |