| 12 Sep 21 | r01        | Atlanta FalconsAtlanta Falco | 6 - 32 | Philadelphia EaglesPhiladelphia |
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| 19 Sep 21 | r02        | Philadelphia EaglesPhiladelphia | 11 - 17 | San Francisco 49ersSan Francisco |
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| 28 Sep 21 | r03        | Dallas CowboysDallas Cowboy | 41 - 21 | Philadelphia EaglesPhiladelphia |
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| 03 Oct 21 | r04        | Philadelphia EaglesPhiladelphia | 30 - 42 | Kansas City ChiefsKansas City C |
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| 10 Oct 21 | r05        | Carolina PanthersCarolina Pant | 18 - 21 | Philadelphia EaglesPhiladelphia |
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| 15 Oct 21 | r06        | Philadelphia EaglesPhiladelphia | 22 - 28 | Tampa Bay BuccaneersTampa Bay Buc |
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| 24 Oct 21 | r07        | Las Vegas RaidersLas Vegas Rai | 33 - 22 | Philadelphia EaglesPhiladelphia |
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| 31 Oct 21 | r08        | Detroit LionsDetroit Lions | 6 - 44 | Philadelphia EaglesPhiladelphia |
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| 07 Nov 21 | r09        | Philadelphia EaglesPhiladelphia | 24 - 27 | Los Angeles ChargersLos Angeles C |
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| 14 Nov 21 | r10        | Denver BroncosDenver Bronco | 13 - 30 | Philadelphia EaglesPhiladelphia |
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| 21 Nov 21 | r11        | Philadelphia EaglesPhiladelphia | 40 - 29 | New Orleans SaintsNew Orleans S |
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| 28 Nov 21 | r12        | New York GiantsNew York Gian | 13 - 7 | Philadelphia EaglesPhiladelphia |
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| 05 Dec 21 | r13        | New York JetsNew York Jets | 18 - 33 | Philadelphia EaglesPhiladelphia |
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| 22 Dec 21 | r15        | Philadelphia EaglesPhiladelphia | 27 - 17 | WashingtonWashington |
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| 26 Dec 21 | r16        | Philadelphia EaglesPhiladelphia | 34 - 10 | New York GiantsNew York Gian |
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| 02 Jan 22 | r17        | WashingtonWashington | 16 - 20 | Philadelphia EaglesPhiladelphia |
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| 09 Jan 22 | r18        | Philadelphia EaglesPhiladelphia | 26 - 51 | Dallas CowboysDallas Cowboy |
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| 16 Jan 22 | Playoff        | Tampa Bay BuccaneersTampa Bay Buc | 31 - 15 | Philadelphia EaglesPhiladelphia |