| 12 Sep 21 | r01        | Buffalo BillsBuffalo Bills | 16 - 23 | Pittsburgh SteelersPittsburgh St |
| |
| 19 Sep 21 | r02        | Pittsburgh SteelersPittsburgh St | 17 - 26 | Las Vegas RaidersLas Vegas Rai |
| |
| 26 Sep 21 | r03        | Pittsburgh SteelersPittsburgh St | 10 - 24 | Cincinnati BengalsCincinnati Be |
| |
| 03 Oct 21 | r04        | Green Bay PackersGreen Bay Pac | 27 - 17 | Pittsburgh SteelersPittsburgh St |
| |
| 10 Oct 21 | r05        | Pittsburgh SteelersPittsburgh St | 27 - 19 | Denver BroncosDenver Bronco |
| |
| 18 Oct 21 | r06        | Pittsburgh SteelersPittsburgh St | 23 - 20 | Seattle SeahawksSeattle Seaha |
| |
| 31 Oct 21 | r08        | Cleveland BrownsCleveland Bro | 10 - 15 | Pittsburgh SteelersPittsburgh St |
| |
| 09 Nov 21 | r09        | Pittsburgh SteelersPittsburgh St | 29 - 27 | Chicago BearsChicago Bears |
| |
| 14 Nov 21 | r10        | Pittsburgh SteelersPittsburgh St | 16 - 16 | Detroit LionsDetroit Lions |
| |
| 22 Nov 21 | r11        | Los Angeles ChargersLos Angeles C | 41 - 37 | Pittsburgh SteelersPittsburgh St |
| |
| 28 Nov 21 | r12        | Cincinnati BengalsCincinnati Be | 41 - 10 | Pittsburgh SteelersPittsburgh St |
| |
| 05 Dec 21 | r13        | Pittsburgh SteelersPittsburgh St | 20 - 19 | Baltimore RavensBaltimore Rav |
| |
| 10 Dec 21 | r14        | Minnesota VikingsMinnesota Vik | 36 - 28 | Pittsburgh SteelersPittsburgh St |
| |
| 19 Dec 21 | r15        | Pittsburgh SteelersPittsburgh St | 19 - 13 | Tennessee TitansTennessee Tit |
| |
| 26 Dec 21 | r16        | Kansas City ChiefsKansas City C | 36 - 10 | Pittsburgh SteelersPittsburgh St |
| |
| 04 Jan 22 | r17        | Pittsburgh SteelersPittsburgh St | 26 - 14 | Cleveland BrownsCleveland Bro |
| |
| 09 Jan 22 | r18        | Baltimore RavensBaltimore Rav | 13 - 16 | Pittsburgh SteelersPittsburgh St |
| |
| 17 Jan 22 | Playoff        | Kansas City ChiefsKansas City C | 42 - 21 | Pittsburgh SteelersPittsburgh St |