| 10 Sep 06 | r01        | Detroit LionsDetroit Lions | 6 - 9 | Seattle SeahawksSeattle Seaha |
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| 17 Sep 06 | r02        | Chicago BearsChicago Bears | 34 - 7 | Detroit LionsDetroit Lions |
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| 24 Sep 06 | r03        | Detroit LionsDetroit Lions | 24 - 31 | Green Bay PackersGreen Bay Pac |
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| 01 Oct 06 | r04        | St. Louis RamsSt. Louis Ram | 41 - 34 | Detroit LionsDetroit Lions |
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| 08 Oct 06 | r05        | Minnesota VikingsMinnesota Vik | 26 - 17 | Detroit LionsDetroit Lions |
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| 15 Oct 06 | r06        | Detroit LionsDetroit Lions | 20 - 17 | Buffalo BillsBuffalo Bills |
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| 22 Oct 06 | r07        | New York JetsNew York Jets | 31 - 24 | Detroit LionsDetroit Lions |
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| 05 Nov 06 | r09        | Detroit LionsDetroit Lions | 30 - 14 | Atlanta FalconsAtlanta Falco |
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| 12 Nov 06 | r10        | Detroit LionsDetroit Lions | 13 - 19 | San Francisco 49ersSan Francisco |
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| 19 Nov 06 | r11        | Arizona CardinalsArizona Cardi | 17 - 10 | Detroit LionsDetroit Lions |
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| 23 Nov 06 | r12        | Detroit LionsDetroit Lions | 10 - 27 | Miami DolphinsMiami Dolphin |
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| 03 Dec 06 | r13        | New England PatriotsNew England P | 28 - 21 | Detroit LionsDetroit Lions |
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| 10 Dec 06 | r14        | Detroit LionsDetroit Lions | 20 - 30 | Minnesota VikingsMinnesota Vik |
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| 17 Dec 06 | r15        | Green Bay PackersGreen Bay Pac | 17 - 9 | Detroit LionsDetroit Lions |
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| 24 Dec 06 | r16        | Detroit LionsDetroit Lions | 21 - 26 | Chicago BearsChicago Bears |
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| 31 Dec 06 | r17        | Dallas CowboysDallas Cowboy | 31 - 39 | Detroit LionsDetroit Lions |