| 10 Sep 06 | r01        | New England PatriotsNew England P | 19 - 17 | Buffalo BillsBuffalo Bills |
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| 17 Sep 06 | r02        | Miami DolphinsMiami Dolphin | 6 - 16 | Buffalo BillsBuffalo Bills |
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| 24 Sep 06 | r03        | Buffalo BillsBuffalo Bills | 20 - 28 | New York JetsNew York Jets |
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| 01 Oct 06 | r04        | Buffalo BillsBuffalo Bills | 17 - 12 | Minnesota VikingsMinnesota Vik |
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| 08 Oct 06 | r05        | Chicago BearsChicago Bears | 40 - 7 | Buffalo BillsBuffalo Bills |
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| 15 Oct 06 | r06        | Detroit LionsDetroit Lions | 20 - 17 | Buffalo BillsBuffalo Bills |
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| 22 Oct 06 | r07        | Buffalo BillsBuffalo Bills | 6 - 28 | New England PatriotsNew England P |
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| 05 Nov 06 | r09        | Buffalo BillsBuffalo Bills | 24 - 10 | Green Bay PackersGreen Bay Pac |
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| 12 Nov 06 | r10        | Indianapolis ColtsIndianapolis | 17 - 16 | Buffalo BillsBuffalo Bills |
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| 19 Nov 06 | r11        | Houston TexansHouston Texan | 21 - 24 | Buffalo BillsBuffalo Bills |
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| 26 Nov 06 | r12        | Buffalo BillsBuffalo Bills | 27 - 24 | Jacksonville JaguarsJacksonville |
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| 03 Dec 06 | r13        | Buffalo BillsBuffalo Bills | 21 - 24 | San Diego ChargersSan Diego Cha |
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| 10 Dec 06 | r14        | New York JetsNew York Jets | 13 - 31 | Buffalo BillsBuffalo Bills |
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| 17 Dec 06 | r15        | Buffalo BillsBuffalo Bills | 21 - 0 | Miami DolphinsMiami Dolphin |
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| 24 Dec 06 | r16        | Buffalo BillsBuffalo Bills | 29 - 30 | Tennessee TitansTennessee Tit |
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| 31 Dec 06 | r17        | Baltimore RavensBaltimore Rav | 19 - 7 | Buffalo BillsBuffalo Bills |