Season Description
The 2000 NFL season was the 81st regular season of the National Football League (NFL). The season ended with Super Bowl XXXV when the Baltimore Ravens defeated the New York Giants, 34–7, at Raymond James Stadium in Tampa, Florida. Week 1 of the season reverted to Labor Day weekend in 2000. It would be the last NFL season to date to start on Labor Day weekend. It would also be the last time until 2015 that CBS televised the late afternoon games in Week 1, because both Week 1 of the NFL season and CBS's coverage of the U.S. Open tennis finals would take place on the same day beginning next season.

Event List
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Round 1
Buffalo Bills vs Tennessee Titans -
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Round 2
Buffalo Bills vs Green Bay Packers -
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Round 3
New York Jets vs Buffalo Bills -
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Round 5
Buffalo Bills vs Indianapolis Colts -
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Round 6
Miami Dolphins vs Buffalo Bills -
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Round 7
Buffalo Bills vs San Diego Chargers -
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Round 8
Minnesota Vikings vs Buffalo Bills -
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Round 9
Buffalo Bills vs New York Jets -
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Round 10
New England Patriots vs Buffalo Bills -
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Round 11
Buffalo Bills vs Chicago Bears -
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Round 12
Kansas City Chiefs vs Buffalo Bills -
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Round 13
Tampa Bay Buccaneers vs Buffalo Bills -
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Round 14
Buffalo Bills vs Miami Dolphins -
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Round 15
Indianapolis Colts vs Buffalo Bills -
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Round 16
Buffalo Bills vs New England Patriots -
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Round 17
Seattle Seahawks vs Buffalo Bills -
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