| 03 Sep 00 | r01        | New Orleans SaintsNew Orleans S | 10 - 14 | Detroit LionsDetroit Lions |
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| 10 Sep 00 | r02        | Detroit LionsDetroit Lions | 15 - 10 | Washington RedskinsWashington Re |
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| 17 Sep 00 | r03        | Detroit LionsDetroit Lions | 10 - 31 | Tampa Bay BuccaneersTampa Bay Buc |
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| 24 Sep 00 | r04        | Chicago BearsChicago Bears | 14 - 21 | Detroit LionsDetroit Lions |
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| 01 Oct 00 | r05        | Detroit LionsDetroit Lions | 24 - 31 | Minnesota VikingsMinnesota Vik |
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| 08 Oct 00 | r06        | Detroit LionsDetroit Lions | 31 - 24 | Green Bay PackersGreen Bay Pac |
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| 19 Oct 00 | r08        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 28 | Detroit LionsDetroit Lions |
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| 29 Oct 00 | r09        | Indianapolis ColtsIndianapolis | 30 - 18 | Detroit LionsDetroit Lions |
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| 05 Nov 00 | r10        | Detroit LionsDetroit Lions | 8 - 23 | Miami DolphinsMiami Dolphin |
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| 12 Nov 00 | r11        | Detroit LionsDetroit Lions | 13 - 10 | Atlanta FalconsAtlanta Falco |
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| 19 Nov 00 | r12        | New York GiantsNew York Gian | 21 - 31 | Detroit LionsDetroit Lions |
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| 23 Nov 00 | r13        | Detroit LionsDetroit Lions | 34 - 9 | New England PatriotsNew England P |
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| 30 Nov 00 | r14        | Minnesota VikingsMinnesota Vik | 24 - 17 | Detroit LionsDetroit Lions |
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| 10 Dec 00 | r15        | Green Bay PackersGreen Bay Pac | 26 - 13 | Detroit LionsDetroit Lions |
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| 17 Dec 00 | r16        | New York JetsNew York Jets | 7 - 10 | Detroit LionsDetroit Lions |
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| 24 Dec 00 | r17        | Detroit LionsDetroit Lions | 20 - 23 | Chicago BearsChicago Bears |