| 03 Sep 00 | r01        | Cleveland BrownsCleveland Bro | 7 - 27 | Jacksonville JaguarsJacksonville |
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| 10 Sep 00 | r02        | Baltimore RavensBaltimore Rav | 39 - 36 | Jacksonville JaguarsJacksonville |
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| 17 Sep 00 | r03        | Jacksonville JaguarsJacksonville | 13 - 0 | Cincinnati BengalsCincinnati Be |
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| 25 Sep 00 | r04        | Indianapolis ColtsIndianapolis | 43 - 14 | Jacksonville JaguarsJacksonville |
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| 01 Oct 00 | r05        | Jacksonville JaguarsJacksonville | 13 - 24 | Pittsburgh SteelersPittsburgh St |
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| 08 Oct 00 | r06        | Jacksonville JaguarsJacksonville | 10 - 15 | Baltimore RavensBaltimore Rav |
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| 16 Oct 00 | r07        | Tennessee TitansTennessee Tit | 27 - 13 | Jacksonville JaguarsJacksonville |
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| 22 Oct 00 | r08        | Jacksonville JaguarsJacksonville | 16 - 35 | Washington RedskinsWashington Re |
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| 29 Oct 00 | r09        | Dallas CowboysDallas Cowboy | 17 - 23 | Jacksonville JaguarsJacksonville |
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| 12 Nov 00 | r11        | Jacksonville JaguarsJacksonville | 21 - 28 | Seattle SeahawksSeattle Seaha |
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| 19 Nov 00 | r12        | Pittsburgh SteelersPittsburgh St | 24 - 34 | Jacksonville JaguarsJacksonville |
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| 26 Nov 00 | r13        | Jacksonville JaguarsJacksonville | 16 - 13 | Tennessee TitansTennessee Tit |
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| 03 Dec 00 | r14        | Jacksonville JaguarsJacksonville | 48 - 0 | Cleveland BrownsCleveland Bro |
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| 10 Dec 00 | r15        | Jacksonville JaguarsJacksonville | 44 - 10 | Arizona CardinalsArizona Cardi |
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| 17 Dec 00 | r16        | Cincinnati BengalsCincinnati Be | 17 - 14 | Jacksonville JaguarsJacksonville |
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| 23 Dec 00 | r17        | New York GiantsNew York Gian | 28 - 25 | Jacksonville JaguarsJacksonville |