| 03 Sep 00 | r01        | Pittsburgh SteelersPittsburgh St | 0 - 16 | Baltimore RavensBaltimore Rav |
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| 17 Sep 00 | r03        | Cleveland BrownsCleveland Bro | 23 - 20 | Pittsburgh SteelersPittsburgh St |
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| 24 Sep 00 | r04        | Pittsburgh SteelersPittsburgh St | 20 - 23 | Tennessee TitansTennessee Tit |
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| 01 Oct 00 | r05        | Jacksonville JaguarsJacksonville | 13 - 24 | Pittsburgh SteelersPittsburgh St |
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| 08 Oct 00 | r06        | New York JetsNew York Jets | 3 - 20 | Pittsburgh SteelersPittsburgh St |
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| 15 Oct 00 | r07        | Pittsburgh SteelersPittsburgh St | 15 - 0 | Cincinnati BengalsCincinnati Be |
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| 22 Oct 00 | r08        | Pittsburgh SteelersPittsburgh St | 22 - 0 | Cleveland BrownsCleveland Bro |
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| 29 Oct 00 | r09        | Baltimore RavensBaltimore Rav | 6 - 9 | Pittsburgh SteelersPittsburgh St |
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| 05 Nov 00 | r10        | Tennessee TitansTennessee Tit | 9 - 7 | Pittsburgh SteelersPittsburgh St |
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| 12 Nov 00 | r11        | Pittsburgh SteelersPittsburgh St | 23 - 26 | Philadelphia EaglesPhiladelphia |
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| 19 Nov 00 | r12        | Pittsburgh SteelersPittsburgh St | 24 - 34 | Jacksonville JaguarsJacksonville |
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| 26 Nov 00 | r13        | Cincinnati BengalsCincinnati Be | 28 - 48 | Pittsburgh SteelersPittsburgh St |
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| 03 Dec 00 | r14        | Pittsburgh SteelersPittsburgh St | 21 - 20 | Oakland RaidersOakland Raide |
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| 10 Dec 00 | r15        | New York GiantsNew York Gian | 30 - 10 | Pittsburgh SteelersPittsburgh St |
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| 16 Dec 00 | r16        | Pittsburgh SteelersPittsburgh St | 24 - 3 | Washington RedskinsWashington Re |
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| 24 Dec 00 | r17        | San Diego ChargersSan Diego Cha | 21 - 34 | Pittsburgh SteelersPittsburgh St |