| 03 Sep 00 | r01        | New England PatriotsNew England P | 16 - 21 | Tampa Bay BuccaneersTampa Bay Buc |
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| 11 Sep 00 | r02        | New York JetsNew York Jets | 20 - 19 | New England PatriotsNew England P |
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| 17 Sep 00 | r03        | New England PatriotsNew England P | 13 - 21 | Minnesota VikingsMinnesota Vik |
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| 24 Sep 00 | r04        | Miami DolphinsMiami Dolphin | 10 - 3 | New England PatriotsNew England P |
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| 01 Oct 00 | r05        | Denver BroncosDenver Bronco | 19 - 28 | New England PatriotsNew England P |
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| 08 Oct 00 | r06        | New England PatriotsNew England P | 24 - 16 | Indianapolis ColtsIndianapolis |
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| 15 Oct 00 | r07        | New England PatriotsNew England P | 17 - 34 | New York JetsNew York Jets |
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| 22 Oct 00 | r08        | Indianapolis ColtsIndianapolis | 30 - 23 | New England PatriotsNew England P |
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| 05 Nov 00 | r10        | New England PatriotsNew England P | 13 - 16 | Buffalo BillsBuffalo Bills |
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| 12 Nov 00 | r11        | Cleveland BrownsCleveland Bro | 19 - 11 | New England PatriotsNew England P |
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| 19 Nov 00 | r12        | New England PatriotsNew England P | 16 - 13 | Cincinnati BengalsCincinnati Be |
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| 23 Nov 00 | r13        | Detroit LionsDetroit Lions | 34 - 9 | New England PatriotsNew England P |
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| 04 Dec 00 | r14        | New England PatriotsNew England P | 30 - 24 | Kansas City ChiefsKansas City C |
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| 10 Dec 00 | r15        | Chicago BearsChicago Bears | 24 - 17 | New England PatriotsNew England P |
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| 17 Dec 00 | r16        | Buffalo BillsBuffalo Bills | 10 - 13 | New England PatriotsNew England P |
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| 24 Dec 00 | r17        | New England PatriotsNew England P | 24 - 27 | Miami DolphinsMiami Dolphin |