| 03 Sep 00 | r01        | Buffalo BillsBuffalo Bills | 16 - 13 | Tennessee TitansTennessee Tit |
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| 10 Sep 00 | r02        | Buffalo BillsBuffalo Bills | 27 - 18 | Green Bay PackersGreen Bay Pac |
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| 17 Sep 00 | r03        | New York JetsNew York Jets | 27 - 14 | Buffalo BillsBuffalo Bills |
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| 01 Oct 00 | r05        | Buffalo BillsBuffalo Bills | 16 - 18 | Indianapolis ColtsIndianapolis |
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| 08 Oct 00 | r06        | Miami DolphinsMiami Dolphin | 22 - 13 | Buffalo BillsBuffalo Bills |
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| 15 Oct 00 | r07        | Buffalo BillsBuffalo Bills | 27 - 24 | San Diego ChargersSan Diego Cha |
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| 22 Oct 00 | r08        | Minnesota VikingsMinnesota Vik | 31 - 27 | Buffalo BillsBuffalo Bills |
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| 29 Oct 00 | r09        | Buffalo BillsBuffalo Bills | 23 - 20 | New York JetsNew York Jets |
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| 05 Nov 00 | r10        | New England PatriotsNew England P | 13 - 16 | Buffalo BillsBuffalo Bills |
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| 12 Nov 00 | r11        | Buffalo BillsBuffalo Bills | 20 - 3 | Chicago BearsChicago Bears |
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| 19 Nov 00 | r12        | Kansas City ChiefsKansas City C | 17 - 21 | Buffalo BillsBuffalo Bills |
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| 26 Nov 00 | r13        | Tampa Bay BuccaneersTampa Bay Buc | 31 - 17 | Buffalo BillsBuffalo Bills |
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| 03 Dec 00 | r14        | Buffalo BillsBuffalo Bills | 6 - 33 | Miami DolphinsMiami Dolphin |
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| 11 Dec 00 | r15        | Indianapolis ColtsIndianapolis | 44 - 20 | Buffalo BillsBuffalo Bills |
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| 17 Dec 00 | r16        | Buffalo BillsBuffalo Bills | 10 - 13 | New England PatriotsNew England P |
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| 23 Dec 00 | r17        | Seattle SeahawksSeattle Seaha | 23 - 42 | Buffalo BillsBuffalo Bills |