| 12 Sep 99 | r01        | Seattle SeahawksSeattle Seaha | 28 - 20 | Detroit LionsDetroit Lions |
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| 19 Sep 99 | r02        | Detroit LionsDetroit Lions | 23 - 15 | Green Bay PackersGreen Bay Pac |
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| 26 Sep 99 | r03        | Kansas City ChiefsKansas City C | 31 - 21 | Detroit LionsDetroit Lions |
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| 10 Oct 99 | r05        | Detroit LionsDetroit Lions | 20 - 10 | Los Angeles ChargersLos Angeles C |
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| 17 Oct 99 | r06        | Detroit LionsDetroit Lions | 25 - 23 | Minnesota VikingsMinnesota Vik |
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| 24 Oct 99 | r07        | Carolina PanthersCarolina Pant | 24 - 9 | Detroit LionsDetroit Lions |
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| 01 Nov 99 | r08        | Detroit LionsDetroit Lions | 20 - 3 | Tampa Bay BuccaneersTampa Bay Buc |
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| 07 Nov 99 | r09        | Detroit LionsDetroit Lions | 31 - 27 | Los Angeles RamsLos Angeles R |
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| 14 Nov 99 | r10        | Arizona CardinalsArizona Cardi | 23 - 19 | Detroit LionsDetroit Lions |
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| 21 Nov 99 | r11        | Green Bay PackersGreen Bay Pac | 26 - 17 | Detroit LionsDetroit Lions |
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| 25 Nov 99 | r12        | Detroit LionsDetroit Lions | 21 - 17 | Chicago BearsChicago Bears |
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| 05 Dec 99 | r13        | Detroit LionsDetroit Lions | 33 - 17 | Washington CommandersWashington Co |
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| 12 Dec 99 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 23 - 16 | Detroit LionsDetroit Lions |
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| 19 Dec 99 | r15        | Chicago BearsChicago Bears | 28 - 10 | Detroit LionsDetroit Lions |
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| 25 Dec 99 | r16        | Detroit LionsDetroit Lions | 17 - 7 | Denver BroncosDenver Bronco |
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| 02 Jan 00 | r17        | Minnesota VikingsMinnesota Vik | 24 - 17 | Detroit LionsDetroit Lions |
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| 08 Jan 00 | Playoff        | Washington CommandersWashington Co | 27 - 13 | Detroit LionsDetroit Lions |