| 12 Sep 99 | r01        | Indianapolis ColtsIndianapolis | 31 - 14 | Buffalo BillsBuffalo Bills |
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| 20 Sep 99 | r02        | Buffalo BillsBuffalo Bills | 17 - 3 | New York JetsNew York Jets |
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| 26 Sep 99 | r03        | Buffalo BillsBuffalo Bills | 26 - 0 | Philadelphia EaglesPhiladelphia |
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| 05 Oct 99 | r04        | Miami DolphinsMiami Dolphin | 23 - 18 | Buffalo BillsBuffalo Bills |
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| 10 Oct 99 | r05        | Buffalo BillsBuffalo Bills | 24 - 21 | Pittsburgh SteelersPittsburgh St |
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| 17 Oct 99 | r06        | Buffalo BillsBuffalo Bills | 20 - 14 | Las Vegas RaidersLas Vegas Rai |
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| 24 Oct 99 | r07        | Seattle SeahawksSeattle Seaha | 26 - 16 | Buffalo BillsBuffalo Bills |
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| 31 Oct 99 | r08        | Baltimore RavensBaltimore Rav | 13 - 10 | Buffalo BillsBuffalo Bills |
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| 07 Nov 99 | r09        | Washington CommandersWashington Co | 34 - 17 | Buffalo BillsBuffalo Bills |
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| 14 Nov 99 | r10        | Buffalo BillsBuffalo Bills | 23 - 3 | Miami DolphinsMiami Dolphin |
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| 21 Nov 99 | r11        | New York JetsNew York Jets | 17 - 7 | Buffalo BillsBuffalo Bills |
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| 28 Nov 99 | r12        | Buffalo BillsBuffalo Bills | 17 - 7 | New England PatriotsNew England P |
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| 12 Dec 99 | r14        | Buffalo BillsBuffalo Bills | 19 - 17 | New York GiantsNew York Gian |
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| 19 Dec 99 | r15        | Arizona CardinalsArizona Cardi | 31 - 21 | Buffalo BillsBuffalo Bills |
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| 26 Dec 99 | r16        | New England PatriotsNew England P | 13 - 10 | Buffalo BillsBuffalo Bills |
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| 02 Jan 00 | r17        | Buffalo BillsBuffalo Bills | 31 - 6 | Indianapolis ColtsIndianapolis |
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| 08 Jan 00 | Playoff        | Tennessee TitansTennessee Tit | 22 - 16 | Buffalo BillsBuffalo Bills |